P100 Syrup Paracetamol Concentration
I cannot provide the specific paracetamol concentration for "P100 syrup" as this product is not identified in the available evidence, drug labels, or guidelines provided.
Standard Paracetamol Syrup Formulations
The most common pediatric paracetamol syrup formulation contains 120-125 mg per 5 mL (24-25 mg/mL). 1, 2
Typical Available Concentrations:
- Standard pediatric syrup: 125 mg/5 mL (2.5% solution, equivalent to 25 mg/mL) 2
- Alternative formulation: 120 mg/5 mL (24 mg/mL) 1
Therefore, 1 mL of standard paracetamol syrup typically contains 24-25 mg of paracetamol. 1, 2
Important Clinical Context
Pediatric Dosing Guidelines:
- Recommended dose: 10-15 mg/kg every 4-6 hours 1, 3
- Maximum daily dose: 60 mg/kg/day (not to exceed 4000 mg/day in adults) 1, 3
- Dosing interval: Every 4 hours, up to 4 doses per day in UK practice; every 4-6 hours up to 60 mg/kg/day in Australian practice 3
Critical Safety Information:
- Toxic dose threshold: Single ingestions >150 mg/kg or >10 grams in adults are potentially hepatotoxic 4
- Chronic toxicity: Repeated doses ≥6 grams or 150 mg/kg per 24-hour period for ≥48 hours carry toxicity risk 4
- High-risk populations: Patients with chronic alcohol use may develop severe hepatotoxicity with doses as low as 4-5 g/day 4
Recommendation for Verification
If you are asking about a specific branded product called "P100 syrup," you must verify the concentration on the product label directly, as formulations vary by manufacturer and country. The standard concentration remains 120-125 mg/5 mL for most pediatric paracetamol syrups globally. 1, 2