From the FDA Drug Label
DOSAGE AND ADMINISTRATION Carefully consider the potential benefits and risks of ibuprofen tablets and other treatment options before deciding to use ibuprofen tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals [see WARNINGS] After observing the response to initial therapy with ibuprofen tablets, the dose and frequency should be adjusted to suit an individual patient's needs. Do not exceed 3200 mg total daily dose.
The FDA drug label does not answer the question.
From the Research
For pediatric dosing of ibuprofen and Tylenol (acetaminophen), the recommended doses are based on the child's weight, with ibuprofen dosed at 10 mg/kg and acetaminophen at 15 mg/kg, as supported by the most recent study 1.
Key Considerations
- Ibuprofen should be given every 6-8 hours, with a maximum daily dose of 40 mg/kg/day or 2400 mg per day, whichever is less.
- Acetaminophen should be dosed every 4-6 hours, with a maximum of 5 doses (or 75 mg/kg/day) in 24 hours, not to exceed 4000 mg daily.
- Both medications work differently, with ibuprofen reducing inflammation and blocking pain signals, and acetaminophen working primarily in the central nervous system to reduce pain perception and fever.
Administration Guidelines
- Use the appropriate measuring device that comes with the medication to ensure accurate dosing.
- Verify the concentration of the liquid formulation, especially for infants.
- Calculate the dose based on the child's most recent weight.
- For infants under 6 months, consult a healthcare provider before giving ibuprofen, as it's not recommended for this age group.
- Give both medications with food to minimize stomach upset, particularly ibuprofen.
Safety and Efficacy
- The most recent study 1 found that combined therapy with ibuprofen and acetaminophen may be superior to single therapy for treating fever in children.
- Another study 2 found similar analgesic efficacy of oral ibuprofen and acetaminophen in comparison with each analgesic alone for short-term treatment of acute pain in the pediatric emergency department.
- A review of the literature 3 found that ibuprofen was more efficacious than acetaminophen for the treatment of pain and fever in both pediatric and adult populations, and that these two drugs were equally safe.