From the FDA Drug Label
In case of overdose, get medical help or contact a Poison Control Center right away. The treatment for Loratadine overdose is to get medical help or contact a Poison Control Center right away 1.
From the Research
Treatment for Loratadine Overdose
- The treatment for loratadine overdose is primarily supportive, as there is no specific antidote for antihistamine overdose 2.
- In cases of excessive doses of loratadine, patients should be monitored for 2 to 3 hours after ingestion, and those ingesting large amounts (approximately >3 to 4 times the normal therapeutic daily dose) should receive medical attention 2.
- A study of a 6-year-old child who intentionally ingested 300 mg of loratadine reported minor elevation of blood pressure and heart rate, which was managed with supportive care only 3.
- The treatment approach may vary depending on the dose and individual response, but overall, loratadine has been shown to have a favorable safety profile with few adverse events 2, 4, 5.
Management of Overdose
- Patients who accidentally ingest excessive doses of loratadine may usually be adequately managed at home, but medical attention is recommended for large overdoses 2.
- Monitoring for potential adverse effects, such as sedation, is important, particularly in patients ingesting cetirizine 2.
- The availability of newer generation antihistamine compounds, including loratadine, has improved the clinical effectiveness and patient tolerance of this class of drugs, with enhanced safety profiles 2, 4.