From the Guidelines
Thyrozol dosing for Basedow's disease should start at 0.5-0.7 mg/kg/day for adults, with a usual maximum initial dose of 40-60 mg daily, as this approach prioritizes minimizing morbidity, mortality, and optimizing quality of life. The provided evidence does not directly address the dosing of Thyrozol for Basedow's disease, but general guidelines for hyperthyroidism treatment can be applied [ 1 ]. It's crucial to note that the evidence provided in [ 1 ] pertains to the management of non-tuberculous mycobacterial pulmonary disease and does not apply to the treatment of Basedow's disease.
Key Considerations for Thyrozol Dosing
- For children, the starting dose is similar at 0.5-0.7 mg/kg/day, divided into 2-3 doses.
- Once clinical improvement occurs (usually within 4-8 weeks), the dose can be gradually reduced to a maintenance dose of 5-15 mg daily or 0.1-0.2 mg/kg/day.
- Thyrozol works by inhibiting thyroid peroxidase, which reduces the production of thyroid hormones.
- Treatment duration typically ranges from 12-18 months, with regular monitoring of thyroid function tests every 4-6 weeks initially, then every 2-3 months once stabilized.
Monitoring and Side Effects
- Side effects to watch for include rash, pruritus, and rarely agranulocytosis.
- Patients should be instructed to seek immediate medical attention if they develop fever, sore throat, or mouth ulcers, which could indicate serious adverse effects.
- Thyroid function should be monitored regularly to adjust dosing appropriately and avoid hypothyroidism [ 1 ].
From the FDA Drug Label
The initial daily dosage is 0.4 mg/kg of body weight divided into 3 doses and given at 8-hour intervals. The dose of Methimazole (Thyrozol) per kg weight in Basedow (Graves' disease) is 0.4 mg/kg of body weight, divided into 3 doses at 8-hour intervals 2.
- Initial dose: 0.4 mg/kg/day
- Administration: divided into 3 doses at 8-hour intervals The maintenance dosage is approximately 1/2 of the initial dose 2.
From the Research
Thyrozol Dose per kg Weight in Basedow
- The studies provided do not directly mention the term "Thyrozol" but rather discuss the treatment of Graves' disease (also known as Basedow's disease) using antithyroid drugs such as methimazole and propylthiouracil 3, 4, 5, 6, 7.
- The dosage of these drugs is mentioned in some studies, but not in the context of "Thyrozol" or a specific dose per kg weight for Basedow's disease.
- For example, one study mentions an initial dose of 30 mg/day of methimazole or 300 mg/day of propylthiouracil for Graves' disease, with doses gradually decreased to a minimum maintenance dose 6.
- Another study discusses the use of methimazole and propylthiouracil in children and adolescents with Graves' disease, with initial doses of <0.75 mg/kg of methimazole and <7.5 mg/kg of propylthiouracil, but does not provide a direct answer to the question of Thyrozol dose per kg weight in Basedow 5.
- Overall, there is no direct evidence in the provided studies to answer the question of Thyrozol dose per kg weight in Basedow.