What is the diagnosis for a patient with a biopsy showing proliferative endometrium (inner lining of the uterus) with foci of tubal metaplasia, and no evidence of endometrial hyperplasia, atypia, or malignancy?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 20, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The biopsy results show proliferative endometrium with tubal metaplasia, which is a benign finding that requires no specific treatment. This means your endometrial tissue is in the normal growth phase of your menstrual cycle, and some areas have cells that resemble fallopian tube cells (tubal metaplasia). Importantly, there is no evidence of hyperplasia (abnormal thickening), cellular atypia (abnormal cells), or cancer. These results are reassuring and typically only require routine follow-up with your gynecologist.

Key Points to Consider

  • Tubal metaplasia is a common, benign change that occurs when endometrial cells transform to resemble fallopian tube cells, often in response to hormonal fluctuations 1.
  • The presence of tubal metaplasia does not increase the risk of developing endometrial hyperplasia or malignancy, as shown in a study with long-term follow-up 1.
  • While no immediate intervention is needed, you should continue with regular gynecological check-ups and report any abnormal bleeding, pelvic pain, or other concerning symptoms to your healthcare provider, as these might warrant further evaluation regardless of these benign findings.
  • It is essential to note that the classification systems for endometrial hyperplasia, such as the WHO system and the EIN system, are used to stratify the risk of progression to cancer, but in this case, there is no evidence of hyperplasia or atypia 2.
  • A recent study published in 2022 highlights the importance of evaluating abnormal uterine and postmenopausal bleeding, but in this case, the biopsy results are benign 3.

References

Research

Tubal metaplasia of the endometrium with cytologic atypia: analysis of p53, Ki-67, TERT, and long-term follow-up.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011

Research

Endometrial Hyperplasia.

Obstetrics and gynecology, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.