Dyanavel Administration Route
No, Dyanavel (amphetamine extended-release oral suspension) is NOT intended for sublingual administration—it must be swallowed orally. 1
Correct Administration Method
- Dyanavel is an oral suspension that must be swallowed, not placed under the tongue 1
- The medication is designed for oral ingestion with absorption occurring through the gastrointestinal tract, similar to other methylphenidate oral solutions 1, 2
- Sublingual administration is explicitly NOT recommended for methylphenidate products because absorption by this route is unpredictable and there is no evidence of clinical advantage over conventional oral routes 3
Why Sublingual Route is Inappropriate
- Methylphenidate (and amphetamine products like Dyanavel) have unpredictable absorption when administered sublingually or buccally 3
- Only highly lipophilic drugs like fentanyl, methadone, and buprenorphine are well-absorbed sublingually—methylphenidate and amphetamines do not have this property 3
- Transmucosal fentanyl formulations (oral, buccal, sublingual) are specifically designed for rapid absorption, but this technology does not apply to ADHD stimulants 3
Proper Dyanavel Dosing Instructions
- Administer the oral suspension by mouth using the provided dosing syringe or cup 1
- The medication should be taken with or without food, though high-fat meals may increase absorption by approximately 25% and delay time to peak concentration by about 1 hour 1
- Do not attempt alternative routes of administration (snorting, injection, sublingual) as these unapproved methods significantly increase the risk of overdose, cardiovascular complications, and death 1
Critical Safety Warning
- Misuse and abuse through unapproved routes of administration (including sublingual, intranasal, or injection) can result in overdose and death, with risk increasing substantially with non-oral routes 1
- Such misuse may cause tachyarrhythmias, hypertension, vasospasm, myocardial infarction, psychosis, seizures, and life-threatening hyperthermia 1