What is the cause of pain on the left lower side of the mouth?

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Last updated: April 20, 2025View editorial policy

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Differential Diagnosis for Left Lower Side Mouth

  • Single most likely diagnosis
    • Tooth abscess or dental infection: This is a common issue that can cause pain and swelling on one side of the mouth, particularly if there's a history of poor dental hygiene or recent dental work.
  • Other Likely diagnoses
    • Gingivitis or periodontitis: Inflammation of the gums can lead to pain and discomfort, often localized to one area if the condition is not widespread.
    • Mouth ulcer: Apthous ulcers or other types of mouth ulcers can cause significant pain and are often found on the inside of the cheeks, lips, or under the tongue, but can also appear on the gum or floor of the mouth.
    • Trauma to the mouth: A bite, cut, or other injury to the inside of the mouth can cause localized pain and swelling.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Oral cancer: Although less common, any persistent or unexplained lesion, especially in smokers or those with a history of tobacco use, should be evaluated for oral cancer.
    • Necrotizing fasciitis: A rare but serious bacterial infection that can start in the mouth and spread rapidly, requiring immediate medical attention.
    • Ludwig's angina: A severe infection of the tissues in the neck, which can start with dental infections and can lead to airway obstruction if not promptly treated.
  • Rare diagnoses
    • Salivary gland stones or infection: While less common, issues with the salivary glands can cause pain, often localized to one side of the mouth or face.
    • Temporomandibular joint (TMJ) disorder: Though more commonly associated with jaw pain, some individuals may experience referred pain to the mouth area.
    • Neuralgias (e.g., trigeminal neuralgia): Rare conditions that affect the nerves and can cause severe, stabbing pain in the face or mouth, often triggered by specific actions like chewing or talking.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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