From the FDA Drug Label
Sertraline was initiated at 25 mg/day for the first week, and then patients were dosed in a range of 50 to 200 mg/day on the basis of clinical response and toleration. The mean sertraline doses for completers to 10 weeks were 131 mg/day and 144 mg/day, respectively, for Studies 1 and 2 The mean sertraline dose for completers was 146 mg/day and 151 mg/day, respectively for Studies 1 and 2
The normal dose of Zoloft (sertraline) is typically initiated at 25 mg/day for the first week, and then dosed in a range of 50 to 200 mg/day based on clinical response and toleration. The average doses for completers in the studies ranged from 131 mg/day to 151 mg/day 1.
From the Research
The normal starting dose of Zoloft (sertraline) for adults with depression or anxiety disorders is typically 50 mg once daily, which can be taken in the morning or evening, as supported by the most recent and highest quality study 2. This dose can be adjusted based on the patient's response and tolerance.
- The dose can be increased in 50 mg increments at weekly intervals, up to a maximum of 200 mg daily, as indicated in the study 3.
- For obsessive-compulsive disorder, the starting dose may be 50 mg daily, with a potential maximum of 200 mg daily.
- For panic disorder, post-traumatic stress disorder, and social anxiety disorder, treatment often begins at 25 mg daily, increasing to 50 mg after one week, as suggested by the guidelines 4.
- Elderly patients and those with liver problems typically start at lower doses, often 25 mg daily. Zoloft works by increasing serotonin levels in the brain, which helps regulate mood, anxiety, and other mental health symptoms, as explained in the study 5. It usually takes 2-4 weeks to notice improvement in symptoms, and the full therapeutic effect may take 6-8 weeks, as reported in the study 6. Take Zoloft at the same time each day with or without food, and don't stop taking it suddenly without consulting your doctor, as this can cause withdrawal symptoms. The most recent study 2 provides an overview of approved psychiatric medications for anxiety disorders, PTSD, and OCD, and highlights the importance of evidence-based treatment. Overall, the recommended dose of Zoloft should be individualized based on the patient's specific needs and medical history, and should be monitored closely by a healthcare professional, as emphasized in the study 2.