From the Research
Multiple sclerosis pain treatment should prioritize a combination of medications and therapies tailored to the specific type of pain experienced, with a focus on anticonvulsants, antidepressants, and non-pharmacological approaches to improve quality of life. For neuropathic pain, first-line medications include anticonvulsants such as gabapentin or pregabalin, as well as tricyclic antidepressants like amitriptyline 1. Key considerations for treatment include:
- Mechanism-based approach for different pain types
- Use of sodium-channel blockers for paroxysmal pain and painful tonic spasms
- Gabapentinoids and antidepressants for ongoing extremity pain
- Non-pharmacological interventions, such as physical therapy and stress management, to complement pharmacological treatments 2, 1. The most effective treatment plan will be individualized, taking into account the patient's specific pain experience, medical history, and response to previous treatments. Regular follow-up with healthcare providers is essential to adjust the treatment plan as needed and minimize side effects, ultimately improving the patient's quality of life 3, 4.