From the FDA Drug Label
- 2 Dose Titration Based Upon Platelet Response Continue the starting dose for at least one week and then titrate to reduce and maintain the platelet count below 600,000/μL, and ideally between 150,000/μL and 400,000/μL. A normal platelet range is ideally between 150,000/μL and 400,000/μL 1.
From the Research
A normal platelet count range for adults is typically between 150,000 and 450,000 platelets per microliter (μL) of blood. This range may vary slightly between different laboratories and healthcare facilities. Platelets, also called thrombocytes, are small cell fragments that play a crucial role in blood clotting and preventing excessive bleeding. If your platelet count falls below 150,000/μL, it's considered thrombocytopenia (low platelets), which may increase bleeding risk. Counts above 450,000/μL indicate thrombocytosis (high platelets), which can potentially increase clotting risk. Platelet counts are routinely measured as part of a complete blood count (CBC). Various factors can affect platelet counts, including certain medications, infections, autoimmune disorders, bone marrow conditions, and pregnancy. Regular monitoring is important for individuals with known platelet disorders or those taking medications that affect platelet function or production.
Key Points to Consider
- The normal platelet range is crucial for assessing bleeding risks and clotting potential.
- Factors such as medications, infections, and autoimmune disorders can influence platelet counts.
- Regular monitoring of platelet counts is essential for managing patients with platelet disorders or those on medications affecting platelet function.
- The provided evidence 2, 3, 4, 5, 6 discusses various aspects of thrombocytopenia and the use of romiplostim, but does not directly impact the definition of a normal platelet range.
Clinical Implications
The management of thrombocytopenia and thrombocytosis involves understanding the normal platelet count range and the factors that can affect it. Romiplostim, as discussed in the studies 2, 3, 4, 5, 6, is a treatment option for certain cases of thrombocytopenia, but the primary concern in clinical practice remains the accurate assessment and management of platelet counts to prevent bleeding or clotting complications.
Evidence Summary
While the studies 2, 3, 4, 5, 6 provide valuable insights into the management of thrombocytopenia and the role of romiplostim, they do not alter the fundamental understanding of what constitutes a normal platelet count range. The most recent and highest quality studies support the established normal range of 150,000 to 450,000 platelets per microliter.