What is the cause of right upper quadrant pain and fever?

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Last updated: April 20, 2025View editorial policy

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Differential Diagnosis for Right Upper Quadrant Pain and Fever

  • Single most likely diagnosis
    • Cholecystitis: This is the most likely diagnosis due to the combination of right upper quadrant pain and fever, which are classic symptoms of inflammation of the gallbladder, often caused by gallstones.
  • Other Likely diagnoses
    • Cholangitis: Infection of the bile ducts, which can cause similar symptoms to cholecystitis, including right upper quadrant pain and fever.
    • Pyelonephritis: Infection of the kidney, which can cause flank pain that may radiate to the right upper quadrant, accompanied by fever.
    • Hepatitis: Inflammation of the liver, which can cause right upper quadrant pain and fever, although it is often accompanied by other symptoms such as jaundice.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Appendicitis: Although appendicitis typically presents with lower right quadrant pain, it can occasionally present with right upper quadrant pain, especially if the appendix is located in a retrocecal position. Missing this diagnosis can lead to perforation and severe complications.
    • Perforated viscus: A hole in the wall of the intestine, which can cause severe abdominal pain, fever, and potentially life-threatening peritonitis if not promptly treated.
    • Liver abscess: A collection of pus in the liver, which can cause right upper quadrant pain, fever, and potentially life-threatening complications if not treated.
  • Rare diagnoses
    • Fitz-Hugh-Curtis syndrome: A rare condition caused by pelvic inflammatory disease spreading to the liver, resulting in right upper quadrant pain and fever.
    • Hepatic artery aneurysm: A rare condition where an aneurysm forms in the hepatic artery, which can cause right upper quadrant pain and potentially life-threatening bleeding if it ruptures.
    • Echinococcal cyst: A rare parasitic infection that can cause cysts to form in the liver, resulting in right upper quadrant pain and fever.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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