What is the cause of increased bruising and swelling in the left knee, extending to the foot and ankle, with nausea, 10 days post total knee arthroplasty (TKA)?

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Differential Diagnosis for Post-Total Knee Replacement Patient

Single Most Likely Diagnosis

  • Deep Vein Thrombosis (DVT): The increase in bruising and swelling to the left knee down to the foot and ankle, especially after a major surgery like total knee replacement, strongly suggests DVT. The recent surgery is a significant risk factor for developing DVT due to immobilization and the hypercoagulable state that often follows such procedures.

Other Likely Diagnoses

  • Infection: Post-surgical infections can cause increased swelling, redness, and warmth around the surgical site. Although the description doesn't specifically mention these signs, infection remains a possibility, especially if there's been a breach in sterile technique during surgery or if the patient has been exposed to infectious agents post-operatively.
  • Hematoma: A collection of blood outside of blood vessels can occur after surgery, leading to swelling and bruising. The symptoms could be consistent with a hematoma, especially if it's expanding or if there's been significant bleeding from the surgical site.
  • Reaction to Medication: Nausea could be a side effect of pain medications or antibiotics commonly used post-surgery. While this doesn't directly explain the swelling and bruising, it's a common issue that can complicate recovery.

Do Not Miss Diagnoses

  • Pulmonary Embolism (PE): Although not directly described, if DVT is suspected, there's always a concern for PE, which can be life-threatening. Symptoms might not always be present, but any shortness of breath, chest pain, or sudden onset of symptoms warrants immediate investigation for PE.
  • Sepsis: Infection leading to sepsis is a life-threatening condition that requires immediate intervention. While the primary symptoms described don't directly point to sepsis, any sign of infection in a post-surgical patient should prompt a thorough evaluation for sepsis.
  • Compartment Syndrome: This is a condition where pressure within the muscles builds to dangerous levels, which can cut off blood flow and prevent nourishment and oxygen from reaching nerve and muscle cells. It's a medical emergency that can result from increased swelling or hematoma formation.

Rare Diagnoses

  • Nerve Injury: Direct injury to nerves during surgery or from swelling/hematoma could lead to unusual sensations, weakness, or specific patterns of numbness. While less common, nerve injuries are a recognized complication of total knee replacement.
  • Arthrofibrosis: Although more of a long-term complication, excessive swelling and bruising could potentially contribute to the development of arthrofibrosis, a condition characterized by decreased range of motion due to scar tissue formation.
  • Rhabdomyolysis: A severe condition where muscle tissue breaks down, potentially due to compartment syndrome or other causes of muscle injury. It's rare but could be considered if there's significant muscle pain or weakness, especially in the context of swelling and bruising.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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