What causes diffuse pain due to inflammation in all body parts?

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Last updated: April 21, 2025View editorial policy

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Differential Diagnosis for Pain from Inflammation in All Body Parts

Single Most Likely Diagnosis

  • Fibromyalgia: A chronic condition characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas. It's a common cause of diffuse body pain and inflammation, often without a clear underlying cause.

Other Likely Diagnoses

  • Rheumatoid Arthritis (RA): An autoimmune disorder that causes inflammation and pain in the joints, potentially leading to widespread body pain if multiple joints are involved.
  • Systemic Lupus Erythematosus (SLE): An autoimmune disease that can affect various parts of the body, including the skin, joints, kidneys, brain, and other organs, causing inflammation and pain.
  • Polymyalgia Rheumatica (PMR): A condition that causes muscle pain and stiffness, typically in the shoulders, hips, and neck, and can be associated with inflammation.

Do Not Miss Diagnoses

  • Septicemia or Sepsis: A life-threatening condition caused by a severe infection that can lead to widespread inflammation and pain. Early recognition and treatment are crucial.
  • Cancer: Certain types of cancer, such as lymphoma or leukemia, can cause systemic inflammation and pain. Although less common, missing a diagnosis of cancer can have severe consequences.
  • Vasculitis: Inflammation of the blood vessels, which can cause pain and inflammation in various parts of the body and can be life-threatening if not treated promptly.

Rare Diagnoses

  • Ehlers-Danlos Syndrome: A group of disorders that affect the connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues, potentially causing widespread pain and inflammation.
  • Relapsing Polychondritis: A rare autoimmune disorder that causes inflammation in the cartilage and other tissues, leading to pain and inflammation in various body parts.
  • Sarcoidosis: A condition in which inflammatory cells (granulomas) form in various organs, potentially causing widespread pain and inflammation, although it more commonly affects the lungs and lymph nodes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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