What are the recommended dosing regimens for sodium‑glucose co‑transporter‑2 (SGLT‑2) inhibitors (empagliflozin, dapagliflozin, canagliflozin, ertugliflozin) in adults with type 2 diabetes, heart failure with reduced ejection fraction, or chronic kidney disease based on estimated glomerular filtration rate?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 7, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What is the recommended dapagliflozin dose for an adult with type 2 diabetes, heart failure with reduced ejection fraction, or chronic kidney disease and an estimated glomerular filtration rate ≥60 mL/min/1.73 m², and how should the dose be adjusted for eGFR 45‑59 mL/min/1.73 m²?
What is the dosing for Dapagliflozin (Forxiga) in patients with Impaired renal function?
Can dapagliflozin be prescribed to an inpatient with type 2 diabetes (or heart failure with reduced ejection fraction or chronic kidney disease) who is euvolemic, has an estimated glomerular filtration rate ≥45 mL/min/1.73 m² (≥30 mL/min/1.73 m² for heart‑failure/CKD), and no acute illness predisposing to euglycemic ketoacidosis?
When to start Dapagliflozin (Forxiga) or Empagliflozin (Jardiance) in a patient with heart failure and chronic kidney disease (CKD)?
What is the estimated glomerular filtration rate (eGFR) cut off for initiating Dapagliflozin (Forxiga) in patients with impaired renal function?
What is the optimal management for an adult with type 2 diabetes and chronic heart failure with reduced ejection fraction?
What prophylaxis should be given to a 5‑month‑old infant who has been exposed to measles from his 6‑year‑old sibling?
Does a systolic blood pressure of 157 mm Hg worsen ovarian cysts or affect the menstrual cycle in a premenopausal woman?
When is lactated Ringer's preferred over 0.9% sodium chloride for isotonic fluid replacement, and what are its contraindications?
A patient with a renal angiomyolipoma that has grown 6 mm over 18 months—what is the appropriate next step?
What is the appropriate cefdinir liquid dose for a 12‑year‑old child weighing 54 kg?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.