What is the medical term for sympathetic nervous system (SNS) predominance?

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From the Guidelines

The medical term for when the sympathetic nervous system predominates is "sympathetic dominance" or "sympathetic hyperactivity". This condition occurs when there is an overactivation of the sympathetic branch of the autonomic nervous system, which is responsible for the "fight-or-flight" response. When sympathetic dominance occurs, the body experiences increased heart rate, elevated blood pressure, dilated pupils, increased sweating, and decreased digestive activity. This physiological state can be triggered by stress, anxiety, certain medications, or underlying medical conditions such as pheochromocytoma or hyperthyroidism. Prolonged sympathetic dominance can contribute to various health issues including hypertension, cardiovascular disease, and anxiety disorders.

Key Points

  • Sympathetic dominance is characterized by an overactivation of the sympathetic nervous system, leading to increased heart rate, blood pressure, and other physiological changes 1.
  • This condition can be triggered by stress, anxiety, or underlying medical conditions, and can contribute to various health issues if left untreated 1.
  • Treatment typically involves addressing the underlying cause, which may include stress management techniques, medications like beta-blockers to reduce sympathetic effects, or treating primary medical conditions.

Importance of Autonomic Balance

The balance between the sympathetic and parasympathetic nervous systems (known as autonomic balance) is crucial for maintaining homeostasis and overall health. Maintaining a healthy balance between these two systems is essential for preventing various health issues, including hypertension, cardiovascular disease, and anxiety disorders 1.

Diagnosis and Treatment

Diagnosis of sympathetic dominance typically involves assessing heart rate variability (HRV) and other physiological markers. Treatment should focus on addressing the underlying cause of sympathetic dominance, which may include stress management techniques, medications, or treating primary medical conditions 1.

From the Research

Sympathetic Nervous System Dominance

The medical term for when the sympathetic nervous system predominates is often referred to as sympathetic overactivity or sympathoneural hypertonicity 2, 3, 4. This condition is characterized by an increased activity of the sympathetic nervous system, which can lead to various health issues, including hypertension, heart failure, and cardiovascular disease.

Key Factors and Conditions

Some key factors and conditions associated with sympathetic nervous system dominance include:

  • Hypertension and associated hypertension-mediated organ damage 2
  • Heart failure (with or without reduced left ventricular ejection fraction) 2
  • Obesity, metabolic syndrome, chronic kidney disease, and obstructive sleep apnea 2
  • Essential hypertension and resistant hypertension 3, 5
  • Ischemic heart disease and sudden cardiac death 4

Therapeutic Interventions

Therapeutic interventions that target the sympathetic nervous system include:

  • Beta-adrenergic blockers 3, 4, 6
  • Selective catheter-based renal sympathetic nerve ablation 3
  • Carotid baroreceptor stimulation 3, 5
  • Centrally acting drugs, such as imidazoline drugs (moxonidine, rilmenidine) 3, 6
  • Renal denervation and carotid baroactivation 5

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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