Differential Diagnosis for Alkaline Phosphatase Elevation in Non-Hepatic Conditions with Deranged Coagulation Profile
- Single Most Likely Diagnosis
- Bone metastasis: This condition can lead to elevated alkaline phosphatase levels due to bone turnover and can also cause a deranged coagulation profile due to the release of tissue factors from the tumor.
- Other Likely Diagnoses
- Paget's disease of bone: A condition characterized by excessive bone breakdown and formation, leading to elevated alkaline phosphatase levels. Coagulation abnormalities can occur due to immobilization or other secondary effects.
- Hyperparathyroidism: Elevated parathyroid hormone levels can cause increased bone resorption, leading to elevated alkaline phosphatase. Coagulation abnormalities can occur due to hypercalcemia.
- Vitamin D deficiency: Severe vitamin D deficiency can cause increased bone turnover, leading to elevated alkaline phosphatase. Coagulation abnormalities can occur due to secondary hyperparathyroidism.
- Do Not Miss Diagnoses
- Osteogenesis imperfecta: A genetic disorder that affects the production of collagen, leading to fragile bones and elevated alkaline phosphatase. Coagulation abnormalities can occur due to the use of warfarin or other anticoagulants.
- Scurvy: Vitamin C deficiency can cause impaired collagen synthesis, leading to elevated alkaline phosphatase. Coagulation abnormalities can occur due to vessel wall fragility.
- Rare Diagnoses
- Hypophosphatasia: A rare genetic disorder that affects the production of alkaline phosphatase, leading to low levels of the enzyme in some forms but elevated in others. Coagulation abnormalities can occur due to the underlying metabolic disorder.
- Fibrodysplasia ossificans progressiva: A rare genetic disorder that causes progressive ossification of soft tissues, leading to elevated alkaline phosphatase. Coagulation abnormalities can occur due to the immobilization or secondary effects of the disease.