How do I take a comprehensive patient history using the OPQRST (Onset, Provocation/Palliation, Quality, Radiation, Severity, Timing) framework and a systematic review of systems?

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Last updated: February 8, 2026View editorial policy

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Taking a Comprehensive Patient History in Medicine

Begin by obtaining the chief complaint and history of present illness using the OPQRST framework, followed by a systematic review of past medical history, medications, social history, family history, and a complete review of systems—all documented in a structured format that prioritizes patient-reported information while maintaining engagement throughout the encounter. 1

History of Present Illness: The OPQRST Framework

When documenting the presenting complaint, systematically address each component:

  • Onset: Document the exact time the patient was last known to be well, who witnessed the symptom onset, and whether onset was sudden or gradual 1
  • Provocation/Palliation: Identify exacerbating conditions (e.g., environmental triggers, activities, body position) and what provides relief 1
  • Quality: Have the patient describe the symptom in their own words (e.g., burning, stinging, pressure, sharp) 1
  • Radiation: Document if symptoms spread to other locations 1
  • Severity: Use validated scales when available or have patients quantify on a 0-10 scale 1
  • Timing: Record duration of symptoms, diurnal fluctuation, and whether symptoms worsen at specific times of day 1

Past Medical History

Systematically document all relevant conditions with year of diagnosis:

  • Cardiovascular: History of hypertension (including blood pressure readings >140/90 mmHg on multiple occasions), heart failure, myocardial infarction, arrhythmias (specifically atrial fibrillation), coronary interventions 1
  • Metabolic: Diabetes (document type, year of onset, treatment method including diet, oral agents, or insulin), dyslipidemia, thyroid disorders 1
  • Infectious: HIV status, hepatitis B and C serology 1
  • Other: Prior surgeries, trauma, seizures, malignancies 1

Medication History

Document with specificity:

  • All current medications including over-the-counter preparations, herbal supplements, and homeopathic remedies 1
  • Anticoagulation therapy status (particularly warfarin) 1
  • Preservatives in topical medications 1
  • For patients with prior treatment: complete antiretroviral or chemotherapy history with cumulative doses 1

Social History

Address high-risk behaviors using direct, non-judgmental questions:

  • Substance use: Smoking status, alcohol consumption, illicit drug use (specifically cocaine, amphetamines) 1
  • Sexual history: Use structured questions such as "Have you had vaginal, anal, or oral sex in the past 12 months?" and "Do you know the HIV status of your partners?" 1
  • Occupational/environmental exposures: Digital screen time, exposure to cardiotoxic substances, radiation exposure 1
  • Living situation: Assess for domestic violence using direct questions or validated screening tools 1

Family History

Document in first-degree relatives (parents, siblings, children):

  • Cardiovascular: Premature coronary disease (age <55 in males, <65 in females), sudden cardiac death, cardiomyopathy, conduction system disease 1
  • Other: Muscular dystrophy, diabetes, hypertension, malignancies 1

Review of Systems

Conduct a systematic organ-based review, asking specifically about:

  • Constitutional: Fever, weight changes, fatigue 1
  • Neurological: Headaches, weakness, sensory changes, seizures 1
  • Cardiovascular: Chest pain, palpitations, edema, orthopnea 1
  • Respiratory: Dyspnea, cough, wheezing 2
  • Gastrointestinal: Nausea, vomiting, diarrhea, constipation 1
  • Genitourinary: Dysuria, frequency, discharge 1
  • Musculoskeletal: Joint pain, muscle weakness 1
  • Dermatological: Rashes, lesions (specifically rosacea, psoriasis) 1
  • Psychiatric: Screen for depression and anxiety using validated tools or direct questions 1

Documentation Strategy During the Encounter

Critical pitfall: Avoid allowing computer documentation to interfere with patient engagement 1

Employ these evidence-based techniques:

  • Review the patient's chart before calling them in 1
  • Start the visit by asking about the patient's concerns and building rapport before computer use 1
  • Maintain body orientation toward the patient, especially lower body positioning 1
  • Explain computer use and verbalize actions (e.g., "I'm looking up your previous lab results") 1
  • Share the screen with the patient when appropriate 1
  • Separate computer work from critical communication moments, particularly when discussing sensitive topics or treatment options 1
  • Consider documenting after the visit for complex or emotionally charged encounters 1

Special Considerations

  • For patients with communication barriers: Obtain history from caregivers closest to the patient when self-report is not possible (e.g., aphasia, cognitive impairment), but document this clearly 1
  • For time-sensitive conditions: Prioritize obtaining time of symptom onset and contraindications to time-sensitive treatments (e.g., anticoagulation status for stroke) 1
  • For sensitive topics: Use validated questionnaires (e.g., OSDI for dry eye, SPEED for symptom tracking) to standardize and facilitate disclosure 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Chronic Shortness of Breath

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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