From the Guidelines
Your creatinine level of 1.42 mg/dL and estimated glomerular filtration rate (GFR) of 66 mL/min/1.73m² indicate mild kidney function impairment, representing Stage 2 chronic kidney disease according to standard classifications, as defined by the National Kidney Foundation practice guidelines 1.
Key Points to Consider
- A GFR level less than 60 mL/min per 1.73 m2 represents loss of half or more of the adult level of normal kidney function, and below this level, the prevalence of complications of chronic kidney disease increases 1.
- The age-related decline in GFR has been considered part of normal aging, but decreased GFR in the elderly is an independent predictor of adverse outcomes, such as death and cardiovascular disease (CVD) 1.
- Clinicians should not use serum creatinine concentration as the sole means to assess the level of kidney function, and clinical laboratories should report an estimate of GFR using a prediction equation in addition to reporting the serum creatinine measurement 1.
Recommendations
- Schedule an appointment with your healthcare provider for further evaluation and monitoring of your kidney function every 6-12 months.
- Maintain blood pressure control and consider dietary modifications such as moderating protein intake and reducing sodium consumption.
- If you have diabetes, maintaining good blood sugar control is essential to prevent further decline in kidney function.
- Certain medications like NSAIDs (ibuprofen, naproxen) should be used cautiously as they can further stress the kidneys.
- Your provider might also check for protein in your urine and evaluate for underlying causes of kidney dysfunction.
Importance of Monitoring and Preventive Measures
- These values suggest your kidneys are functioning at about two-thirds of normal capacity, which is why monitoring and preventive measures are important to prevent further decline.
- Early detection and management of chronic kidney disease can help prevent progression to more advanced stages and reduce the risk of complications.
From the Research
Understanding Creatinine and GFR Levels
- Creatinine level of 1.42 and GFR of 66 indicate a potential decline in kidney function, as a normal GFR is typically above 90 mL/min/1.73m² 2.
- Serum creatinine is a commonly used marker of kidney function, but it has its limitations, including being insensitive to mild or moderate decreases in GFR 3.
Interpreting GFR and Creatinine Values
- A GFR of 66 suggests that the kidneys are not functioning at optimal levels, which may require monitoring and potential treatment adjustments 2.
- The creatinine level of 1.42 is slightly elevated, which may indicate a decline in kidney function or other underlying health issues 3.
Clinical Implications and Management
- Accurate assessment of kidney function is crucial for diagnosis, treatment, and medication dosing, highlighting the importance of regular monitoring and potential adjustments to treatment plans 2, 4.
- The use of ACE inhibitors or ARBs may be beneficial in managing patients with chronic kidney disease, but their effectiveness and potential impact on kidney function should be carefully evaluated 5, 4.
- In cases of rhabdomyolysis or acute kidney injury, aggressive hydration and monitoring of creatinine levels are essential for preventing further kidney damage 6.