What is the recommended daily dose of Tri‑Vi‑Sol (multivitamin supplement) for an exclusively or partially breast‑fed infant under 12 months of age?

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Tri-Vi-Sol Dosing for Breastfed Infants Under 12 Months

For exclusively or partially breastfed infants under 12 months of age, administer 1 mL of Tri-Vi-Sol daily, which provides 400 IU of vitamin D, 1500 IU of vitamin A, and 35 mg of vitamin C.

Essential Vitamin D Supplementation

  • All breastfed infants require 400 IU of vitamin D daily starting at hospital discharge and continuing throughout the entire breastfeeding period, regardless of whether breastfeeding is exclusive or partial. 1

  • Breast milk contains insufficient vitamin D to meet infant requirements, making supplementation mandatory for all breastfed babies. 1

  • Supplementation should continue as long as breastfeeding continues—there is no upper age limit for discontinuation based on the infant's age alone. 1

  • The standard 1 mL dose of Tri-Vi-Sol provides the recommended 400 IU of vitamin D. 1

Additional Vitamins in Tri-Vi-Sol

  • The vitamin A content (1500 IU per mL) falls within safe ranges for term infants, as guidelines recommend 700-1500 IU/kg/day for preterm infants, suggesting adequate safety margins for term babies. 2

  • The vitamin C content (35 mg per mL) exceeds minimum requirements but remains well below toxic levels, as parenteral doses of 15-25 mg/kg/day are considered safe for infants. 3

  • A standard multivitamin dose of 0.5-1.0 mL is considered adequate for infants with chronic conditions requiring supplementation. 3

Critical Administration Guidelines

  • Begin supplementation in the first days of life at hospital discharge. 1

  • Continue daily administration without interruption throughout breastfeeding. 1

  • For formula-fed infants, discontinue Tri-Vi-Sol only when the infant consistently consumes at least 28 ounces of vitamin D-fortified formula daily. 1

Alternative Maternal Supplementation Strategy

  • Lactating mothers can alternatively take 6400 IU of vitamin D daily instead of direct infant supplementation, providing adequate vitamin D through breast milk. 1

  • This maternal approach must continue throughout the entire breastfeeding period. 1

Common Pitfalls to Avoid

  • Never discontinue supplementation at an arbitrary age (such as 6 months)—base the decision on feeding method and volume, not age alone. 1

  • Do not assume that introducing solid foods eliminates the need for vitamin D supplementation in breastfed infants. 1

  • Ensure the product used is specifically formulated for infants—adult multivitamin formulations containing propylene glycol and polysorbate must never be used due to toxicity risk. 2, 4

References

Guideline

Vitamin D Supplementation Guidelines for Infants

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Multivitamin Supplementation in Infants Under 6 Months

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Vitamin K Dosing for Preterm Infants

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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