In a newborn with delayed umbilical cord separation and bleeding from the cord site, normal prothrombin time, normal activated partial thromboplastin time, normal platelet count and function, and isolated prolonged clot formation time, which is the most likely diagnosis: Factor VIII deficiency, von Willebrand disease, Factor XIII deficiency, or thrombocytopenia?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 9, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What is the appropriate management for a patient with persistent bleeding, anemia, prolonged PT and aPTT, and decreased factor eight activity following a dental procedure?
What is the likely cause of a newborn's delayed umbilical cord separation and bleeding with normal Prothrombin Time (PT), Partial Thromboplastin Time (PTT), and platelet count and function, but delayed clotting time?
What is the management approach for a child with umbilical bleeding, normal Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), platelet count, and platelet function, but increased clot lysis, with a family history of similar issues?
What is the next step to investigate a prolonged activated partial thromboplastin time (APTT) with a normal thrombin time and no evidence of heparin use?
What is the likely diagnosis for a 2-day-old patient with hemarthrosis, normal platelet count, and prolonged partial thromboplastin time (PTT) that does not correct with mixing study, in the absence of family history?
Why should furosemide (Lasix) be held in a hyponatremic patient—especially if serum sodium is <130 mEq/L, the patient is symptomatic, elderly, has heart failure or cirrhosis, or is on other diuretics?
What are the recommended treatment options for hepatitis A, hepatitis B (acute and chronic), hepatitis C, hepatitis D, and hepatitis E?
What are the first‑line hormone therapy recommendations, including dose, route, and progestogen use, for a typical woman aged 45‑60, within 10 years of menopause, who has bothersome vasomotor symptoms, night sweats, urogenital atrophy, or desires early bone loss protection and has no contraindications?
What is the appropriate assessment and management plan for a young adult female with a one‑week history of right neck swelling diagnosed as viral lymphadenopathy, now presenting with bilateral conjunctival injection (viral conjunctivitis), a left submandibular lymph node, and currently on amoxicillin/clavulanate?
What is the appropriate oral levosalbutamol dose for children, including weight‑based dosing, minimum dose, dosing interval, and age‑specific limits?
What starting dose of quetiapine (Seroquel) should be added to an antidepressant for a patient with depression and insomnia?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.