From the FDA Drug Label
Atomoxetine capsules should be initiated at a total daily dose of approximately 0.5 mg/kg and increased after a minimum of 3 days to a target total daily dose of approximately 1.2 mg/kg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. Atomoxetine capsules should be initiated at a total daily dose of 40 mg and increased after a minimum of 3 days to a target total daily dose of approximately 80 mg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening.
The best time to take atomoxetine is in the morning, either as a single daily dose or as part of a divided dose regimen that includes a late afternoon/early evening dose. This is based on the dosing instructions provided in the drug label. 1
From the Research
Atomoxetine is typically best taken in the morning. This medication, used to treat ADHD, works by increasing levels of norepinephrine in the brain to improve attention and reduce impulsivity. Morning dosing is generally recommended because atomoxetine can take several hours to reach peak effectiveness, allowing the medication to work during daytime hours when focus is most needed. Some people may experience insomnia as a side effect, making morning administration preferable to avoid sleep disruptions. However, if you experience significant nausea or drowsiness after taking atomoxetine, your doctor might suggest taking it in the evening instead. The medication can be taken with or without food, though taking it with food may help reduce stomach upset. It's essential to take atomoxetine at the same time each day to maintain consistent blood levels. Always follow your prescriber's specific instructions, as dosing recommendations may vary based on your individual response to the medication and other health factors.
According to the most recent study 2, atomoxetine has been shown to be effective in reducing core symptoms of ADHD, but the study does not specifically address the optimal timing of administration. Another study 3 examined the effects of atomoxetine on behavioral inhibition and motor impulsivity in rats, but it does not provide guidance on the best time of day to take the medication. An earlier study 4 assessed the effects of atomoxetine on impulsivity in juvenile rats, but it also does not address the optimal timing of administration. A more recent review 5 of pharmacotherapies for methamphetamine/amphetamine use disorder mentions atomoxetine as one of the medications evaluated, but it does not provide information on the best time of day to take the medication.
In terms of specific considerations, it's crucial to weigh the potential benefits of morning dosing, such as improved focus and attention during daytime hours, against potential side effects like insomnia. If you experience significant side effects, your doctor may recommend adjusting the timing of your atomoxetine dose. Ultimately, the decision on when to take atomoxetine should be based on your individual needs and response to the medication, as well as your prescriber's guidance.
Key points to consider:
- Take atomoxetine at the same time each day to maintain consistent blood levels
- Morning dosing is generally recommended to allow the medication to work during daytime hours
- If you experience significant side effects, your doctor may recommend adjusting the timing of your dose
- Always follow your prescriber's specific instructions, as dosing recommendations may vary based on your individual response to the medication and other health factors.