Dukoral Dosing Information Not Available in Provided Evidence
I cannot provide specific dosing recommendations for Dukoral (oral cholera vaccine) because none of the evidence provided contains official prescribing information, FDA labeling, or current guideline recommendations specifically addressing Dukoral's dosing schedule and booster timing across age groups.
What the Available Evidence Shows
The research studies provided discuss Dukoral only in the context of:
Limited efficacy in young children: Dukoral offered negative protection in children under 5 years of age in a Peruvian field trial, and only 15% protection in those over 6 years during the first year 1
Age restrictions in current recommendations: Dukoral is recommended for adults and only children over 2 years of age 2
Research on immunogenicity enhancement: A study in 6-18 month old Bangladeshi children showed two doses were safe and induced vibriocidal antibody responses in 57% of children, with enhanced responses when breast-feeding was temporarily withheld or zinc supplementation was provided 2
Immune response differences by age: Adults and older children mount class-switched IgG and IgA antibody responses to O-specific polysaccharide, while younger children (ages 2 to <5) primarily mount IgM responses with minimal IgA and IgG 3
Critical Gap
The provided evidence lacks:
- Official manufacturer dosing schedules
- Specific timing between doses
- Booster dose recommendations and intervals
- Age-specific dosing modifications
- Current FDA or WHO prescribing guidelines for Dukoral
Clinical Context
The evidence suggests Dukoral has questionable effectiveness in the populations most vulnerable to cholera (children under 5 years), with concerns about vaccine composition using V. cholerae O1 strains from 1947 that have been heat and formalin inactivated 1. Alternative vaccines (Shanchol, Euvichol) are discussed in the research but are not the subject of your question 4.
To obtain accurate Dukoral dosing information, consult the official FDA prescribing information or current WHO/CDC cholera vaccination guidelines.