From the FDA Drug Label
To keep AZELEX Cream away from the mouth, eyes and other mucous membranes. The FDA drug label does not answer the question.
From the Research
Perioral dermatitis should be treated with oral tetracycline as the first line of therapy, especially in severe cases, as it has the strongest evidence supporting its efficacy, as shown in the study by 1 and 2. The condition is a common inflammatory skin disorder characterized by small red bumps, pustules, and mild scaling around the mouth, nose, and sometimes eyes. Some key points to consider in the treatment of perioral dermatitis include:
- Stopping the use of topical corticosteroids, as they can worsen the condition, as noted in the study by 3
- Avoiding heavy moisturizers, fluorinated toothpaste, and facial products with potential irritants
- Using a gentle skincare routine, including washing with lukewarm water and a mild, non-soap cleanser
- Considering topical metronidazole, erythromycin, or pimecrolimus as alternative treatment options, as suggested in the study by 1 and 4
- Maintaining gentle skincare practices even after resolution to prevent recurrence, as perioral dermatitis can recur due to disruption of the skin barrier and overgrowth of skin microorganisms, as mentioned in the study by 5 It's essential to note that the etiology of perioral dermatitis remains unclear, but topical corticosteroid misuse is considered a principal causative factor, as found in the systematic review by 3. In terms of treatment, oral tetracycline has the strongest evidence supporting its efficacy, and it should be considered as the first line of therapy, especially in severe cases, as shown in the study by 1 and 2.