From the Guidelines
The dose of Ativan (Lorazepam) for seizure management is 0.2 mg/kg, with a maximum of 6 mg per dose, and may be repeated every 10-15 minutes.
Seizure Management with Lorazepam
- The initial dose of lorazepam for seizure management is 0.2 mg/kg, with a maximum dose of 6 mg per dose 1.
- This dose may be repeated every 10-15 minutes as needed 1.
- It is essential to note that lorazepam is typically used for initial IV treatment of status epilepticus, and other benzodiazepines may also be considered.
- In cases of refractory status epilepticus, a loading dose of 0.15-0.20 mg/kg may be followed by a continuous infusion, but this is not the standard initial treatment 1.
- Monitoring of oxygen saturation and preparation for respiratory support is crucial when administering lorazepam, especially when combined with other sedative agents 1.
From the Research
Dose of Ativan (Lorazepam) for Seizure Management
The dose of Ativan (Lorazepam) for seizure management varies depending on the specific condition and patient population.
- For adults with status epilepticus, a dose of 4 to 5 mg is recommended 2.
- For children aged 6-14 years with acute seizures, a dose of 0.1 mg/kg (maximum 4 mg) is used 3.
- For adults with generalized convulsive status epilepticus, a dose of 0.1 mg per kilogram of body weight is used 4.
- For adults with convulsive status epilepticus, a dose of 4 mg i.v. is recommended 5.
- For adults with prolonged or repetitive seizures, a dose of 0.5 to 2 mg of sublingual lorazepam oral concentrate solution is used 6.
Administration Routes
Lorazepam can be administered through various routes, including:
Efficacy and Safety
Lorazepam has been shown to be effective in terminating seizures and preventing recurrence, with a relatively low incidence of adverse events 3, 4, 5, 6. However, sedation is a common side effect, particularly at higher doses 6.