How should a rectal suppository be inserted in a newborn infant?

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How to Insert a Rectal Suppository in a Newborn

Preparation and Positioning

Position the newborn on their side (lateral decubitus position) or on their back with knees flexed toward the chest to optimize access to the rectum. 1

  • Ensure the infant is calm and comfortable before beginning the procedure 1
  • Have all necessary supplies ready, including the suppository, water-soluble lubricant, and gloves 2
  • Wear clean gloves to maintain hygiene and prevent contamination 2

Suppository Preparation

  • Remove the suppository from its wrapper just before insertion 2
  • Lubricate the suppository generously with water-soluble lubricant to minimize discomfort and facilitate insertion 2
  • The suppository should be at room temperature or slightly warmed in your hand to prevent shock from cold temperature 2

Insertion Technique

Insert the suppository pointed end first (not blunt end first) into the rectum, as recommended by most manufacturers and standard clinical practice. 3

  • Gently separate the buttocks with one hand to visualize the anal opening 2
  • Insert the lubricated suppository approximately 1-2 cm (about half the length of your little finger) into the rectum in newborns 2
  • Use gentle, steady pressure—never force the suppository if you meet resistance 2
  • Aim the suppository toward the umbilicus (anteriorly) to follow the natural curve of the rectum 2
  • Hold the buttocks together gently for 1-2 minutes after insertion to prevent immediate expulsion 2

Important Caveats and Pitfalls

Avoid rectal suppositories in extremely preterm neonates with intestinal concerns, as they may develop intestinal hemorrhage (hematochezia). 1

  • Do not use excessive force during insertion, as the rectal mucosa in newborns is delicate and prone to trauma 2
  • Be aware that the evidence for "blunt end first" insertion comes from a single 1991 study that has not been adequately replicated, while manufacturers consistently recommend pointed end first 3
  • Monitor for signs of rectal bleeding or discomfort after insertion 1
  • For medications like glycerin suppositories used for constipation relief, these are appropriate for short-term use only 4

Special Considerations for Newborns

  • Newborns have smaller rectal vaults, so insertion depth should be minimal (1-2 cm maximum) 2
  • The suppository will dissolve at body temperature, typically within 15-30 minutes 2
  • For systemic medications given rectally, absorption may be variable in neonates due to immature hepatic metabolism 5, 6
  • Many drugs used rectally in newborns are off-label, as most medications lack adequate neonatal safety data 5, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Administering a suppository.

Nursing times, 2007

Guideline

Treatment Options for Constipation in Newborns

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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