From the Guidelines
An iron saturation of 85% with low UIBC suggests iron overload, which requires further evaluation and potential treatment to prevent complications such as cirrhosis, heart failure, and diabetes. Given the high iron saturation level, it is essential to consult with a healthcare provider for additional testing, including serum ferritin levels and possibly genetic testing for hereditary hemochromatosis, the most common cause of iron overload 1. The healthcare provider may recommend therapeutic phlebotomy (blood removal) if hemochromatosis is confirmed, typically starting with weekly or biweekly sessions until iron levels normalize, then maintenance phlebotomies every 2-4 months 1. Dietary modifications are also crucial, including:
- Limiting alcohol consumption
- Avoiding iron supplements
- Avoiding vitamin C with meals
- Reducing intake of red meat It is also important to note that iron overload can deposit in organs like the liver, heart, and pancreas, potentially causing severe complications if left untreated 1. Early intervention can prevent these complications, so prompt medical attention is essential. The use of MRI for detection and non-invasive quantification of iron can also be helpful in guiding diagnosis and management, especially in patients with suspected iron overload disorder 1.