How should I manage a peritonsillar abscess in a teenage or adult patient presenting with unilateral sore throat, fever, muffled 'hot‑potato' voice, uvular deviation away from the lesion, and trismus?

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Management of Peritonsillar Abscess

The management of peritonsillar abscess in teenagers and adults requires immediate drainage combined with antibiotics targeting group A streptococcus and oral anaerobes, with most patients successfully managed as outpatients. 1

Immediate Treatment Algorithm

Source Control (Drainage) - Essential First Step

Drainage is absolutely essential and antibiotics alone should not be relied upon for treatment success. 1 You have three equivalent drainage options:

  • Needle aspiration - simplest approach, can be performed in office/ED 2, 3
  • Incision and drainage - traditional surgical approach 4, 3
  • Quinsy tonsillectomy (immediate tonsillectomy) - reserved for select cases 3, 5

All three methods yield successful results, and the choice depends on provider experience and patient factors. 3 The key is that pus must be removed from the abscess cavity. 4

Antibiotic Therapy

Initiate empiric antibiotics immediately once diagnosis is made, targeting group A streptococcus and oral anaerobes. 1 Continue antibiotics for 3-5 days after adequate source control has been achieved. 1 Avoid potentially nephrotoxic agents like aminoglycosides. 1

Supportive Care

  • Hydration: Provide adequate IV or oral hydration, as volume depletion is common from fever, poor oral intake, and tachypnea 1
  • Pain control: Use ibuprofen, acetaminophen, or both for adequate analgesia, which is essential for maintaining oral intake and hydration 1
  • Corticosteroids: Consider adjunctive steroids to reduce symptoms and speed recovery 2, 3, 5

Disposition Decision

Outpatient Management (Most Patients)

Most patients can be managed as outpatients with the combination of drainage, antibiotics, steroids, and pain control. 1, 2

Inpatient Admission Required For:

  • Severe systemic symptoms 1
  • Inability to maintain hydration 1
  • Signs of sepsis 1
  • Concern for airway obstruction 6
  • Risk of aspiration 6, 2
  • Extension of infection into deep neck tissues 6, 2

Monitoring and Follow-Up

Monitor all patients for potential complications including airway obstruction, aspiration, or extension into deep neck tissues. 6 These complications, though rare, can be life-threatening and require emergent surgical intervention if inadequately treated. 4

Definitive Treatment Consideration

For patients with recurrent peritonsillar abscess (more than one episode), tonsillectomy should be considered as definitive treatment. 6, 1 This represents a modifying factor that favors tonsillectomy even if standard criteria for recurrent tonsillitis are not met. 1

Note that unilateral tonsillectomy carries a 14% risk of developing contralateral streptococcal tonsillitis and 7% risk of contralateral peritonsillar complications. 1

Critical Pitfalls to Avoid

  • Never rely on antibiotics alone without drainage - source control is essential 1
  • Don't miss atypical presentations - in older patients without history of recurrent tonsillitis, consider malignancy (lymphoma or squamous cell carcinoma) if tonsillar hypertrophy persists after treatment 7
  • Don't underestimate hydration needs - aggressive fluid replacement is crucial 1
  • Don't delay treatment - prompt recognition and therapy prevent serious complications 2

References

Guideline

Treatment of Peritonsillar Abscess

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Peritonsillar Abscess.

American family physician, 2017

Research

The contemporary approach to diagnosis and management of peritonsillar abscess.

Current opinion in otolaryngology & head and neck surgery, 2005

Research

[Diagnosis and treatment of peritonsillar abscess].

Duodecim; laaketieteellinen aikakauskirja, 2010

Guideline

Peritonsillar Abscess Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Lymphoma presenting as a peritonsillar abscess.

European annals of otorhinolaryngology, head and neck diseases, 2013

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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