What is the ICD‑10‑CM code for current use of a proton‑pump inhibitor (PPI)?

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Last updated: February 11, 2026View editorial policy

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ICD-10-CM Code for Current PPI Use

The ICD-10-CM code for current use of a proton pump inhibitor is Z79.899 (Other long-term [current] drug therapy).

Primary Code Selection

  • Z79.899 is the appropriate code for documenting current PPI use when the medication is being taken for ongoing therapeutic purposes 1
  • This code falls under the category of "Persons with potential health hazards related to family and personal history and certain conditions influencing health status" 1

Clinical Context for Code Assignment

  • The code should be assigned when PPIs are being used for documented indications such as:
    • Gastroesophageal reflux disease (GERD) 1, 2
    • Prevention of GI bleeding in patients on antithrombotic therapy (anticoagulants or antiplatelet agents) 3, 4
    • History of peptic ulcer disease 2
    • Barrett's esophagus 4, 2
    • Erosive esophagitis 4, 2
    • Concurrent NSAID or aspirin use with bleeding risk factors 4, 5

Important Documentation Considerations

  • Always document the underlying indication for PPI therapy alongside the Z79.899 code, as appropriate use requires a valid clinical indication 1, 6
  • The primary diagnosis code (such as K21.9 for GERD or history of GI bleeding) should be listed first, with Z79.899 as a secondary code 1
  • For patients on dual antiplatelet therapy (DAPT) or anticoagulants, the European Society of Cardiology recommends documenting the specific bleeding risk factors that justify PPI use 3

Common Pitfalls to Avoid

  • Do not use Z79.899 for short-term PPI therapy (less than several weeks) - this code is specifically for long-term or current ongoing use 1
  • Studies show that 52-65% of PPI prescriptions in skilled nursing facilities lack appropriate diagnostic codes, leading to regulatory concerns and unnecessary medication costs 1
  • Ensure the medical record clearly documents why the PPI is indicated, as regulations require that drug regimens be free from unnecessary medications 1, 6
  • Regular review of PPI continuation is essential - approximately 25% of users continue PPIs for more than 1 year, and 28% for more than 3 years, often without ongoing indication 6

References

Research

An overview of proton pump inhibitors.

Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 2003

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Proton Pump Inhibitors with Anticoagulants

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Management of Anticoagulants and Antiplatelets During GI Bleeding

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Proton pump inhibitor use: systematic review of global trends and practices.

European journal of clinical pharmacology, 2023

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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