Maximum Daily Dose of Zuclopenthixol
I cannot provide a definitive answer regarding the maximum daily dose of zuclopenthixol because none of the provided evidence directly addresses zuclopenthixol dosing guidelines or maximum daily doses.
Evidence Review
The provided studies focus exclusively on:
Tuberculosis treatment medications (streptomycin, amikacin, kanamycin, cycloserine, ethionamide) with detailed maximum daily doses ranging from 750-1000 mg depending on the specific antitubercular agent 1
Unrelated medications including Mounjaro (tirzepatide) for diabetes 2, meclizine for allergic reactions 3, and investigational retatrutide 4
Zuclopenthixol research studies that examine:
- Comparative effectiveness in elderly patients starting at 4 mg daily 5
- Serum concentration monitoring with depot formulations (50-500 mg every 14 days for zuclopenthixol decanoate) 6
- Minimum effective maintenance doses (200 mg/2 weeks for depot formulation, range 60-400 mg) 7
- Pharmacokinetic comparisons 8, 9
Critical Gap
No guideline, drug label, or authoritative source in the provided evidence specifies the maximum daily dose for oral or injectable zuclopenthixol formulations. The research studies mention starting doses of 4 mg daily in elderly patients 5 and depot formulations up to 500 mg every 2 weeks 6, but these do not establish maximum daily dosing limits for acute or maintenance treatment.
To answer this question accurately, I would require access to:
- FDA-approved prescribing information for zuclopenthixol
- International psychiatric treatment guidelines (e.g., British National Formulary, European guidelines)
- Manufacturer's product monograph