From the Research
Optimal Oral Prednisone Regimen for Severe Atopic Dermatitis Exacerbation
- The optimal oral prednisone regimen for a severe atopic dermatitis exacerbation is not explicitly stated in the provided studies 1, 2, 3, 4, 5.
- However, it is mentioned that systemic corticosteroids, such as prednisone, are rapidly effective but should only be used short-term for severe exacerbations due to their many long-term side effects 1.
- A study on the rebound phenomenon to systemic corticosteroid in atopic dermatitis suggests that systemic corticosteroids may exacerbate the acute phase of atopic dermatitis, mediated by IgE, accentuating the Th2 pattern in these patients 3.
- Another study on the reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient found that corticosteroids can be effective in reducing relapses, but does not provide information on oral prednisone regimen 4.
- Expert perspectives on management of moderate-to-severe atopic dermatitis suggest that systemic steroids, such as prednisone, are not recommended by current guidelines and are commonly associated with disease rebound 5.
Key Considerations
- Systemic corticosteroids, such as prednisone, should only be used short-term for severe exacerbations due to their many long-term side effects 1.
- The use of systemic corticosteroids may exacerbate the acute phase of atopic dermatitis, mediated by IgE, accentuating the Th2 pattern in these patients 3.
- Corticosteroids can be effective in reducing relapses, but the optimal oral prednisone regimen is not explicitly stated in the provided studies 4.
- Current guidelines do not recommend systemic steroids, such as prednisone, for moderate-to-severe atopic dermatitis due to the risk of disease rebound 5.