From the Guidelines
Dizziness and vertigo are recognized side effects of hydroxyurea, and patients experiencing these symptoms should report them to their healthcare provider but continue their medication unless instructed otherwise. According to the most recent guidelines, hydroxyurea can cause neurologic disturbances, including headache, dizziness, disorientation, hallucinations, and convulsions, although these are rare 1. The exact mechanism of dizziness and vertigo in patients taking hydroxyurea is not well understood, but it may be related to the drug's effects on blood cell production or blood pressure, or it could be an indirect effect from anemia if the red blood cell count is low.
Some key points to consider when taking hydroxyurea include:
- Staying well-hydrated and changing positions slowly (especially when standing up) may help minimize dizziness symptoms
- Regular blood tests during hydroxyurea treatment are important to monitor for bone marrow suppression, which could contribute to dizziness symptoms
- Other common side effects of hydroxyurea include bone marrow suppression, gastrointestinal issues, and skin changes
- The initial dose of hydroxyurea is typically 500 mg orally twice daily, increasing to 1.5 g/d as tolerated, and patients should be monitored regularly for signs of toxicity and adverse effects 1
It's essential for patients to work closely with their healthcare provider to manage any side effects and adjust their treatment plan as needed. Patients should never adjust their hydroxyurea dose themselves, and any concerns about side effects should be discussed with their healthcare provider. By prioritizing regular monitoring and open communication with their healthcare provider, patients can minimize the risks associated with hydroxyurea and maximize its benefits.
From the Research
Hydroxyurea Side Effects: Dizziness or Vertigo
- There is no direct evidence in the provided studies that links hydroxyurea to dizziness or vertigo as a side effect 2, 3, 4, 5, 6.
- The studies primarily focus on the efficacy and safety of hydroxyurea in treating sickle cell anemia and other conditions, with side effects such as macrocytic anemia, fever reactions, and allergic reactions being reported 2.
- None of the studies specifically mention dizziness or vertigo as a side effect of hydroxyurea therapy 3, 4, 5, 6.
- One study examines the effects of hydroxyurea on brain function in children with sickle cell anemia, but it does not report dizziness or vertigo as a side effect 6.
- Overall, there is a lack of evidence to suggest that dizziness or vertigo is a common side effect of hydroxyurea therapy, but it is essential to consult with a healthcare professional for personalized advice 2, 3, 4, 5, 6.