From the Research
Dose and Duration of Olanzapine and Baclofen
- The dose and duration of olanzapine and baclofen for intractable hiccups management are not explicitly stated in the provided studies, except for a case report where a combination of baclofen and low-dose olanzapine therapy was used to control intractable hiccups 1.
- Baclofen has been studied in a prospective manner and in randomized controlled trials, and has been found to be successful in treating hiccups 2, 3, 4.
- The use of baclofen is supported by small randomized, placebo-controlled trials, and observational data suggest that it is less likely to cause side effects during long-term therapy compared to standard neuroleptic agents 3.
- A double-blind, randomized, controlled, cross-over study found that baclofen consistently and significantly improved hiccup severity, both subjectively and by hiccup-free periods 4.
Pharmacological Treatment Options
- Several pharmacologic treatment options have been proposed for intractable and persistent hiccups, including amitriptyline, baclofen, gabapentin, haloperidol, metoclopramide, midazolam, nifedipine, nimodipine, orphenadrine, and valproic acid 2.
- Baclofen, gabapentin, and metoclopramide were the only agents that were studied in a prospective manner, and only baclofen and metoclopramide were studied in randomized controlled trials 2.
- Dopamine-blocking medications, baclofen, and gabapentin, along with anticonvulsants, have been found to be useful in treating intractable hiccups 5.