Maximum Toujeo Dose Per Injection
The Toujeo Max SoloStar pen can deliver a maximum single dose of 80 units per injection. 1
Toujeo Pen Specifications
The Toujeo (insulin glargine U-300) Max SoloStar pen is specifically designed for patients requiring higher insulin doses:
- Maximum single dose capacity: 80 units 1
- Total pen capacity: 300 units (1.5 mL of U-300 insulin) 1
- Dose increments: 1 unit 1
- Minimum dose: 1 unit 1
This allows for multiple injections from a single pen, with the plunger moving incrementally with each dose until all 300 units have been dispensed. 1
Key Differences from Standard Insulin Glargine (Lantus)
Toujeo contains three times the concentration of standard insulin glargine (300 units/mL vs. 100 units/mL), which provides important clinical advantages:
- Flatter and longer pharmacokinetic profile extending beyond 24 hours 2
- Lower intra- and inter-patient variability with more reproducible effects 2
- Reduced risk of nocturnal hypoglycemia compared to U-100 glargine 2
- Slightly higher total daily dose requirement due to modestly lower per-unit efficacy 3, 2
Critical Dosing Considerations
Toujeo and Lantus are NOT bioequivalent unit-for-unit. 2 When switching from U-100 glargine or other basal insulins to Toujeo:
- Expect to need approximately 10-18% higher total daily dose with Toujeo 2
- Intensify blood glucose monitoring during the transition period 2
- Dose adjustments should be made based on individual glycemic response 2
Proper Injection Technique
To ensure accurate dose delivery with the Toujeo Max SoloStar pen:
- Prime the pen before each injection by dialing 2 units and pressing the injection button until insulin appears at the needle tip 1
- Use a new sterile needle for every injection to prevent blocked needles and contamination 1
- Press the injection button all the way in and keep pressure on it until the needle is completely withdrawn 1, 4
- Rotate injection sites within your chosen area (abdomen, thighs, upper arms) to prevent lipodystrophy 1
- Never share pens between patients, even with needle changes, due to contamination risk 1
When Single Injections Are Insufficient
If you consistently require more than 80 units per dose:
- Split the total dose into two separate injections at different injection sites 4
- Consider twice-daily Toujeo administration rather than once daily, which may provide better glycemic control in highly insulin-resistant patients 5
- The concentrated U-300 formulation already reduces injection volume compared to U-100 insulins, making higher doses more tolerable 3, 2