What is the safety and efficacy of Ashwagandha (Withania somnifera) for patients with diabetes mellitus?

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Last updated: April 22, 2025View editorial policy

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From the Guidelines

Ashwagandha should be used with caution by diabetics as it may lower blood sugar levels, potentially causing interactions with diabetes medications. While some research suggests ashwagandha may help improve insulin sensitivity and reduce blood glucose levels at doses of 250-500mg daily, diabetic patients should consult their healthcare provider before using it. The herb contains compounds called withanolides that may enhance insulin secretion and improve glucose uptake in muscle cells, which explains its potential benefits but also its risks. Diabetics who choose to use ashwagandha should start with a lower dose (around 250mg daily) and monitor blood glucose levels closely, as dosage adjustments to diabetes medications may be necessary. Signs of hypoglycemia (low blood sugar) such as dizziness, confusion, or excessive sweating should prompt immediate medical attention. Additionally, ashwagandha quality varies between products, so choosing standardized extracts from reputable manufacturers is important for consistent effects.

Some key points to consider when using ashwagandha for diabetes management include:

  • Monitoring blood glucose levels closely to avoid hypoglycemia
  • Starting with a low dose (around 250mg daily) and adjusting as needed
  • Consulting with a healthcare provider before using ashwagandha, especially if taking diabetes medications
  • Choosing a high-quality, standardized ashwagandha extract from a reputable manufacturer

According to the American Diabetes Association, there is no clear evidence that dietary supplementation with herbs, such as ashwagandha, can improve outcomes in people with diabetes who do not have underlying deficiencies 1. However, some studies suggest that ashwagandha may have a positive effect on insulin sensitivity and blood glucose levels 1. It is essential to weigh the potential benefits and risks of using ashwagandha for diabetes management and to consult with a healthcare provider before adding it to a treatment plan.

In terms of safety and efficacy, the most recent and highest-quality study on ashwagandha for diabetes management is not explicitly stated in the provided evidence. However, based on the available information, it is clear that ashwagandha should be used with caution and under the guidance of a healthcare provider to minimize potential risks and interactions with diabetes medications. Further research is needed to fully understand the effects of ashwagandha on diabetes management and to establish clear guidelines for its use.

Overall, while ashwagandha may have potential benefits for diabetes management, its use should be approached with caution and careful consideration of the potential risks and interactions with diabetes medications. Diabetic patients should consult with their healthcare provider before using ashwagandha and should prioritize monitoring their blood glucose levels and adjusting their treatment plan as needed.

From the Research

Ashwagandha Safety and Efficacy for Diabetics

  • There is limited research directly addressing the safety and efficacy of Ashwagandha for diabetics.
  • A study on the safety of Ashwagandha root extract in healthy volunteers found that consumption for 8 weeks was safe in both males and females volunteers 2.
  • However, the study did not specifically investigate the effects of Ashwagandha on diabetic patients.
  • Another study investigated the effect of Ashwagandha supplementation on anxiety and stress, but not specifically on diabetes management 3.
  • Research on diabetes management has focused on conventional medications such as metformin, sulfonylureas, and thiazolidinediones, with metformin appearing to have a good safety profile for the risk of fracture 4, 5.
  • A study comparing the effects of propolis or metformin on glycemic control in patients with type 2 diabetes mellitus found that both propolis and metformin reduced fasting plasma glucose and glycated hemoglobin A1c levels 6.
  • However, more research is needed to determine the safety and efficacy of Ashwagandha for diabetic patients.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The use of metformin, insulin, sulphonylureas, and thiazolidinediones and the risk of fracture: Systematic review and meta-analysis of observational studies.

Obesity reviews : an official journal of the International Association for the Study of Obesity, 2019

Research

Anti-hyperglycemic effects of propolis or metformin in type 2 diabetes mellitus.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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