Acute Bacterial Sinusitis with Unilateral Headache
Your symptoms of nasal congestion with sharp pain radiating to the left temple strongly suggest acute bacterial sinusitis, and you should start amoxicillin-clavulanate 875 mg/125 mg twice daily for 10-14 days, combined with intranasal corticosteroids and saline irrigation. 1, 2, 3
Clinical Diagnosis
Your presentation fits the classic pattern of acute bacterial sinusitis:
- Nasal congestion with purulent rhinorrhea, facial/dental pain, and headache are the hallmark symptoms of acute bacterial sinusitis in adults 1
- Unilateral temple pain radiating from the sinuses indicates maxillary or frontal sinus involvement, which commonly presents with facial pressure and headache 1
- Pain over the sinuses is a key distinguishing feature that separates bacterial sinusitis from viral upper respiratory infections 1
When Antibiotics Are Indicated
You should receive antibiotics if you meet any of these criteria:
- Symptoms persisting ≥10 days without improvement (purulent discharge plus obstruction or facial pain) 2
- Severe symptoms: fever ≥39°C lasting ≥3-4 consecutive days with purulent discharge and facial pain 2
- "Double sickening": initial improvement followed by worsening after 5-6 days 2
First-Line Antibiotic Treatment
Amoxicillin-clavulanate 875 mg/125 mg twice daily is the preferred first-line antibiotic, not plain amoxicillin, because:
- It provides 90-92% predicted efficacy against the three most common pathogens: Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis 2
- The clavulanate component covers β-lactamase-producing organisms (30-40% of H. influenzae and M. catarrhalis isolates produce β-lactamase) 2
- Treatment duration should be 10-14 days, or continue for 7 days after symptoms resolve 1, 3
Essential Adjunctive Therapies (Not Optional)
You must add intranasal corticosteroids and saline irrigation—these are not optional add-ons:
- Intranasal corticosteroids (fluticasone, mometasone, or budesonide) twice daily reduce mucosal inflammation and accelerate symptom resolution, with strong RCT evidence 2, 4
- High-volume saline nasal irrigation 2-3 times daily clears mucus and reduces edema 2
- Analgesics (acetaminophen or ibuprofen) for pain control 3
Reassessment Timeline
You must be reassessed at specific intervals—do not wait indefinitely:
- At 3-5 days: If no improvement, switch to high-dose amoxicillin-clavulanate (2 g/125 mg twice daily) or a respiratory fluoroquinolone 1, 2, 3
- At 7 days: If symptoms persist or worsen, reconfirm the diagnosis and exclude complications 2
Red Flags Requiring Urgent Evaluation
Seek immediate medical attention if you develop any of these:
- Orbital swelling, pain, or visual changes (diplopia, proptosis) 1
- Swelling of the forehead 1
- Severe headache with altered mental status 2
- Periorbital inflammation, edema, or erythema 1
These symptoms suggest orbital cellulitis, meningitis, or intracranial abscess—life-threatening complications requiring urgent CT imaging and possible surgical intervention 1, 2
What NOT to Do
Avoid these common pitfalls:
- Do not obtain routine CT imaging for uncomplicated acute sinusitis—up to 87% of viral URIs show sinus abnormalities on imaging, which cannot differentiate bacterial from viral disease 2
- Do not use macrolides (azithromycin)—resistance exceeds 20-25% for S. pneumoniae and H. influenzae 2
- Do not use trimethoprim-sulfamethoxazole—resistance rates are 50% for S. pneumoniae 2
- Do not use first-generation cephalosporins (cephalexin)—inadequate coverage against β-lactamase-producing H. influenzae 2
Penicillin Allergy Alternatives
If you have a penicillin allergy:
- Non-severe allergy: Use a second- or third-generation cephalosporin (cefuroxime, cefpodoxime, or cefdinir) for 10 days—cross-reactivity is negligible 2
- Severe/anaphylactic allergy: Use a respiratory fluoroquinolone (levofloxacin 500 mg daily for 10-14 days or moxifloxacin 400 mg daily for 10 days) 2
When to Refer to ENT
Refer to otolaryngology if: