From the Guidelines
Effect of Triamcinolone on Blood Glucose Levels
The administration of triamcinolone injections can cause a significant increase in blood glucose levels.
- The onset of this effect is usually observed within 2-6 hours post-injection, with peak effects occurring between 12-24 hours 1.
- The duration of elevated blood sugar levels can persist for 3-5 days, depending on the dose and individual patient factors, with return to baseline glucose levels typically occurring within 5-7 days after injection.
- Glucocorticoid type and duration of action must be considered in determining insulin treatment regimens, as different types of glucocorticoids have varying effects on blood glucose levels 1.
- For patients on morning steroid regimens, disproportionate hyperglycemia during the day is common, but they frequently reach normal blood glucose levels overnight regardless of treatment 1.
- Intermediate-acting insulin, such as NPH, is often administered in addition to daily basal-bolus insulin or oral anti-diabetes medications to manage hyperglycemia induced by glucocorticoids 1.
- Long-acting insulin may be required to control fasting blood glucose levels in patients on long-acting glucocorticoids, such as dexamethasone, or multidose or continuous glucocorticoid use 1.
- Adjustments based on anticipated changes in glucocorticoid dosing and point-of-care glucose test results are critical to managing hyperglycemia induced by triamcinolone injections 1.
From the FDA Drug Label
Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. Studies indicate that following a single intramuscular dose of 60 mg to 100 mg of triamcinolone acetonide, adrenal suppression occurs within 24 to 48 hours and then gradually returns to normal, usually in 30 to 40 days.
The effect of Triamcinolone (Kenalog) injection on blood glucose levels is an increase in blood glucose concentrations. The timing of this effect is not explicitly stated in terms of peak effects, but adrenal suppression, which may be related to the effect on blood glucose, occurs within 24 to 48 hours after a single intramuscular dose and returns to normal within 30 to 40 days 2 2.
- Key points:
- Increase in blood glucose concentrations
- Adrenal suppression within 24 to 48 hours
- Return to normal within 30 to 40 days
- Clinical decision: Monitor blood glucose levels and adjust antidiabetic agents as needed to manage the increase in blood glucose concentrations caused by triamcinolone acetonide injection.
From the Research
Effect of Triamcinolone (Kenalog) Injection on Blood Glucose Levels
There are no research papers to assist in answering this question, as the provided studies do not investigate the effect of Triamcinolone (Kenalog) injection on blood glucose levels.
Relevant Information from Provided Studies
- The studies provided focus on different topics, including the use of triamcinolone acetonide injections to prevent stricture after esophageal endoscopic submucosal dissection 3, the safety and pharmacokinetics of S-(-)-pantoprazole sodium injections 4, and the clinical meaningfulness of scores on the Amsterdam Instrumental Activities of Daily Living Questionnaire 5.
- None of these studies mention the effect of Triamcinolone (Kenalog) injection on blood glucose levels, including timing and peak effects.
Key Points
- The provided studies do not address the question of the effect of Triamcinolone (Kenalog) injection on blood glucose levels.
- Further research is needed to determine the impact of Triamcinolone (Kenalog) injection on blood glucose levels.