From the Guidelines
Albumin is primarily created in the liver. Specifically, hepatocytes (liver cells) are responsible for synthesizing this important protein, which is then released into the bloodstream 1. The liver produces about 10-15 grams of albumin daily, making it one of the body's most abundant proteins. Some key points to consider about albumin production include:
- Albumin synthesis is a complex process that involves transcription of the albumin gene, translation of mRNA, and post-translational modifications before the completed protein is secreted.
- The production of albumin is regulated by various factors including nutritional status, hormones, and inflammatory mediators.
- When liver function is compromised, as in conditions like cirrhosis or hepatitis, albumin production may decrease, leading to hypoalbuminemia, as noted in the guidelines on the management of abnormal liver blood tests 1. This explains why blood albumin levels are often used as a marker of liver function in clinical settings, highlighting the liver's crucial role in albumin production 1.
From the Research
Albumin Creation
- Albumin is created in the liver, as stated in the studies 2, 3, 4
- The liver produces albumin at a rate of about 10.5 g/day in normal humans, as mentioned in the study 5
- The synthesis of albumin is influenced by various factors, including nutritional status, energy supply, and hormonal modulation, as discussed in the study 3
- The liver's ability to synthesize albumin can be impaired in certain conditions, such as liver disease, leading to reduced albumin production, as noted in the studies 2, 5