What are the diagnostic criteria to differentiate Polycythemia Vera (PV) from other causes of erythrocytosis, characterized by an elevated Red Blood Cell (RBC) count?

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Last updated: April 22, 2025 • View editorial policy

Differential Diagnosis for High RBC Count

To distinguish between polycythemia vera and other causes of high RBC count, consider the following categories:

  • Single Most Likely Diagnosis + Polycythemia Vera: This is a myeloproliferative neoplasm characterized by the excessive production of RBCs, WBCs, and platelets. It is the most likely diagnosis when considering primary causes of elevated RBC counts due to its direct involvement in RBC overproduction.
  • Other Likely Diagnoses + Dehydration: A common cause of relative polycythemia, where the concentration of RBCs appears elevated due to decreased plasma volume. + Chronic Hypoxia: Conditions such as chronic obstructive pulmonary disease (COPD), sleep apnea, or living at high altitudes can lead to increased erythropoietin production, stimulating RBC production. + Testosterone Replacement Therapy: Exogenous testosterone can stimulate erythropoiesis, leading to an increase in RBC count.
  • Do Not Miss Diagnoses + Renal Cell Carcinoma: Some renal cell carcinomas can produce erythropoietin, leading to secondary polycythemia. Missing this diagnosis could delay the treatment of a potentially curable cancer. + Hepatocellular Carcinoma: Though less common, some hepatocellular carcinomas can also produce erythropoietin, leading to increased RBC production. + Phlebotomy-Induced Iron Deficiency in Polycythemia Vera: In patients with polycythemia vera, frequent phlebotomies can lead to iron deficiency, which might mask the diagnosis or complicate management.
  • Rare Diagnoses + Erythropoietin-Producing Tumors (e.g., Pheochromocytoma, Hemangioblastoma): These are rare tumors that can produce erythropoietin, leading to increased RBC production. + Congenital Polycythemia: A rare condition characterized by an increase in RBC mass due to genetic mutations affecting the erythropoietin receptor or other pathways involved in erythropoiesis. + Chuvash Polycythemia: A rare genetic disorder leading to an increase in RBC count due to a mutation in the von Hippel-Lindau (VHL) gene, affecting the regulation of erythropoietin production.

Each of these diagnoses has distinct clinical and laboratory features that can help in differentiation. A thorough diagnostic workup, including complete blood counts, serum erythropoietin levels, bone marrow biopsy, and genetic testing, is essential for accurate diagnosis and management.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.