Do sertraline (Zoloft), gabapentin, atorvastatin, estradiol 0.01% cream, testosterone capsules, Lumine Organics supplement, and nitric‑oxide booster tablets increase blood pressure?

Blood Pressure Effects of Your Medication Regimen

Most of the medications you listed do not significantly increase blood pressure, with the notable exception that testosterone can raise blood pressure, and nitric oxide boosters should theoretically lower it—though the specific supplement formulations you're taking lack clinical data on their cardiovascular effects.

Individual Medication Analysis

Sertraline (Zoloft) - Does NOT Increase Blood Pressure

• Sertraline is an SSRI (selective serotonin reuptake inhibitor) and does not cause blood pressure elevation 1, 2.
• The International Society of Hypertension guidelines explicitly state that SSRIs like sertraline have "no increases in blood pressure" and are preferred over SNRIs in patients with hypertension 1, 2.
• This is in contrast to SNRIs (serotonin-norepinephrine reuptake inhibitors), which can increase blood pressure by approximately 2/1 mmHg 1.

Gabapentin - Does NOT Increase Blood Pressure

• Gabapentin is not listed among medications known to increase blood pressure in major hypertension guidelines 1.
• It does not appear in the comprehensive tables of blood pressure-elevating substances from the International Society of Hypertension 1.

Atorvastatin - Does NOT Increase Blood Pressure

• Atorvastatin (a statin) is not recognized as a medication that increases blood pressure 1.
• In fact, the International Society of Hypertension notes that atorvastatin may have urate-lowering properties, which could theoretically benefit cardiovascular risk 1.

Estradiol 0.01% Cream - Minimal to No Effect

• Low-dose topical estradiol (0.01%) has minimal systemic absorption and is unlikely to significantly affect blood pressure 1.
• The International Society of Hypertension guidelines indicate that blood pressure increases occur with high-dose oral contraceptive pills containing >50 mcg of estrogen, which cause a 6/3 mmHg increase 1.
• Your 0.01% topical cream delivers far less systemic estrogen than these oral formulations and should not meaningfully impact blood pressure 1.

Testosterone Capsules - CAN Increase Blood Pressure

• Testosterone supplementation is not explicitly listed in the International Society of Hypertension guidelines, but falls under the category of hormonal agents that can affect blood pressure 1.
• Testosterone can increase blood pressure through multiple mechanisms including sodium retention, increased red blood cell mass, and effects on vascular tone 3.
• If you have hypertension, blood pressure should be monitored regularly while on testosterone therapy 1.

Lumine Organics Supplement - Unknown/Insufficient Data

• This specific supplement is not mentioned in clinical guidelines or medical literature 1.
• Without knowing the specific ingredients, it's impossible to determine blood pressure effects 1.
• The International Society of Hypertension warns that herbal substances including ma-huang, high-dose ginseng, licorice, St. John's wort, and yohimbine can increase blood pressure 1.
• You should review the ingredient list for these specific compounds 1.

Nitric Oxide Booster Tablets - Should LOWER Blood Pressure

• Nitric oxide is a vasodilator and should theoretically lower blood pressure, not raise it 1.
• However, the specific formulation and ingredients in commercial "nitric oxide booster" supplements vary widely and lack rigorous clinical data 1.
• Some may contain stimulants or other compounds that could counteract the vasodilatory effects 1.

Clinical Recommendations

Monitoring Strategy

• Screen for blood pressure changes if you're taking testosterone, as this is the medication most likely to affect your blood pressure 1.
• Review the complete ingredient lists of your supplements (Lumine Organics and nitric oxide booster) for known blood pressure-elevating substances 1.
• The International Society of Hypertension recommends screening all patients for substances that may increase blood pressure or interfere with antihypertensive therapy 1.

Key Pitfalls to Avoid

• Do not assume all supplements are benign—many herbal products can significantly affect blood pressure 1.
• The effect of medications on blood pressure is highly variable between individuals, with greater increases noted in the elderly, those with higher baseline blood pressure, or those with kidney disease 1.
• If blood pressure becomes elevated, consider reducing or eliminating substances that raise blood pressure, though if these substances are required, blood pressure should be treated to target regardless 1.