Best Birth Control for Heavy Periods
Combined oral contraceptives containing 30-35 μg ethinyl estradiol with levonorgestrel or norgestimate are the recommended first-line treatment for heavy menstrual bleeding when contraception is also desired. 1
First-Line Hormonal Treatment
Start with a monophasic combined oral contraceptive (COC) containing 30-35 μg ethinyl estradiol combined with levonorgestrel or norgestimate. 1, 2 This formulation:
- Reduces menstrual blood loss by inducing regular shedding of a thinner endometrium 1
- Decreases menstrual cramping 2
- Provides additional benefits including acne improvement and reduced risk of endometrial and ovarian cancers 1, 2
Practical Implementation
- No backup contraception is needed if started within the first 5 days of menstrual bleeding 2
- If started more than 5 days after bleeding onset, use backup contraception (condoms) for 7 days 2
- Counsel patients that irregular bleeding during the first 3-6 months is common, generally not harmful, and typically resolves with continued use 1, 2
Managing Breakthrough Bleeding
If heavy or prolonged bleeding persists despite COC therapy:
- Add NSAIDs (mefenamic acid 500 mg three times daily, or ibuprofen) for 5-7 days during bleeding episodes, which reduces menstrual blood loss by 20-60% acutely 1
- For extended/continuous COC regimens, consider a 3-4 day hormone-free interval (but never during the first 21 days of use and not more than once per month) 1, 2
- Rule out pregnancy, sexually transmitted infections, medication interactions, or new uterine pathology (polyps, fibroids) before treating breakthrough bleeding 2
Superior Alternative: Levonorgestrel-Releasing Intrauterine System (LNG-IUS)
The LNG-IUS is the most effective medical treatment for heavy menstrual bleeding, reducing blood loss by 71-95%, which is superior to all oral medications. 3, 4, 5
When to Choose LNG-IUS Over COCs
The LNG-IUS should be strongly considered when:
- Estrogen-containing contraceptives are contraindicated (hypertension, history of thromboembolism, migraine with aura, smoking over age 35) 3
- Oral medication adherence is a concern 6
- Maximum reduction in menstrual blood loss is the priority 4, 7
- Long-term contraception (5-7 years) is desired 6
LNG-IUS Benefits
- Achieves 71-95% reduction in menstrual blood loss, comparable to endometrial ablation 3, 4, 5
- Improves anemia markers 3
- Minimal systemic hormonal absorption, avoiding blood pressure elevation 3
- More cost-effective than endometrial ablation or hysterectomy 4, 5
- Improves quality of life comparably to surgical options 5
LNG-IUS Counseling Points
- Irregular bleeding or spotting is common during the first 3-6 months after insertion but typically resolves 3, 6
- Many women develop amenorrhea after 6-12 months, which is beneficial for heavy bleeding and not harmful 6, 8
- Enhanced pre-insertion counseling about expected bleeding patterns markedly reduces premature removal and increases satisfaction 6
- Backup contraception needed only if inserted more than 7 days after menses starts (7 days of backup) 2
Safety Considerations for COCs
Before prescribing combined oral contraceptives, assess for contraindications:
- COCs increase venous thromboembolism risk 3-4 fold (up to 4 per 10,000 woman-years) 2, 3
- Avoid in severe or uncontrolled hypertension 3
- Monitor blood pressure at follow-up visits 1, 2
- Smoking is NOT a contraindication in women under age 35 2
Alternative Options
Progestin-Only Methods
If estrogen is contraindicated but LNG-IUS is declined:
- Depot medroxyprogesterone acetate (DMPA) 150 mg intramuscularly every 12 weeks can reduce bleeding 2
- For heavy bleeding with DMPA, add NSAIDs for 5-7 days 2
- Amenorrhea is common after ≥1 year of continuous DMPA use 2
- Caution: DMPA causes fluid retention and is contraindicated in heart failure 2
Contraceptive Vaginal Ring
- NuvaRing releases 15 μg ethinyl estradiol and 120 μg etonogestrel daily 2
- Provides comparable effectiveness to COCs with simpler once-monthly insertion 2
Treatment Algorithm
- Rule out underlying pathology: pregnancy, infection, structural lesions (fibroids, polyps), bleeding disorders 1
- First choice for most women: Monophasic COC with 30-35 μg ethinyl estradiol + levonorgestrel or norgestimate 1, 2
- If COCs contraindicated or maximum efficacy needed: LNG-IUS 3, 4
- If breakthrough bleeding on COCs: Add NSAIDs for 5-7 days 1
- If bleeding persists beyond 3-6 months: Re-evaluate for underlying gynecological problems 1
- If medical management fails: Counsel about endometrial ablation or hysterectomy 1