How many grams are in a bottle of Miralax (polyethylene glycol 3350)?

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Last updated: February 12, 2026 • View editorial policy

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MiraLAX Bottle Sizes

MiraLAX (polyethylene glycol 3350) is available over-the-counter in an 8.3-ounce bottle containing 238 grams of powder. 1

Standard Bottle Content

  • The standard OTC bottle contains 238 grams (8.3 ounces) of PEG 3350 powder 1
  • This provides approximately 14 daily doses when using the FDA-approved dose of 17 grams per day 1

Clinical Dosing Context

  • The recommended dose for occasional constipation is 17 grams once daily, mixed in 4-8 ounces of liquid 1, 2
  • One bottle (238 grams) therefore contains enough powder for roughly 2 weeks of treatment at the standard dose 1
  • Some studies have used 306 grams rather than the standard 238-gram bottle for bowel preparation protocols 1

Practical Considerations

  • The powder should be mixed with at least 4 ounces, preferably 8 ounces of any beverage (water, juice, soda, coffee, or tea) 2
  • Insufficient liquid volume is a common cause of treatment failure—patients must use adequate fluid for the osmotic mechanism to work effectively 2, 3
  • For chronic constipation management, patients may require multiple bottles as treatment response is durable for up to 6 months 1, 2

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

2
Guideline

Polyethylene Glycol 3350 (MiraLAX) for Chronic Constipation – Evidence‑Based Recommendations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

3
Guideline

Management of Constipation with PEG 3350 and Rectal Therapy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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