Mounjaro Does Not Affect Caffeine Duration
There is no evidence that Mounjaro (tirzepatide) alters the duration of caffeine's pharmacologic effects. The provided evidence contains no data on interactions between tirzepatide and caffeine metabolism, absorption, or elimination.
Mechanism of Action Context
Tirzepatide is a dual GIP/GLP-1 receptor agonist that primarily affects glucose metabolism and gastric emptying 1, 2. Its main pharmacodynamic effects include:
- Delayed gastric emptying through GLP-1 receptor activation, which slows the transit of food and medications through the gastrointestinal tract 1
- Glucose-dependent insulin secretion from pancreatic beta cells 1
- Reduced glucagon secretion in hyperglycemic states 1
- Decreased appetite and food intake 2
Theoretical Considerations
While tirzepatide delays gastric emptying 1, this mechanism would theoretically only affect the absorption rate of orally consumed caffeine, not its duration of action. Caffeine's duration of effect is determined by its hepatic metabolism (primarily via CYP1A2) and renal elimination—pathways that tirzepatide does not influence based on available evidence.
Documented Drug Interactions
The only documented pharmacokinetic interaction with tirzepatide involves warfarin, where delayed gastric emptying may indirectly affect INR values 3. However, this represents an absorption-related effect rather than a change in drug duration or metabolism 3.
Clinical Bottom Line
Caffeine can be consumed normally while taking Mounjaro without concern for altered duration of caffeine effects. The absence of any reported interaction in clinical trials 1, 4 or post-marketing surveillance 5 supports the safety of concurrent use. If gastric emptying delays caffeine absorption, patients might experience a slightly delayed onset of caffeine effects, but not prolonged duration.