What are the options for pain management in patients with ovarian cysts?

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Last updated: February 16, 2025 • View editorial policy

From the Guidelines

Pain management for ovarian cysts typically involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, 400-800mg every 6-8 hours, or acetaminophen, 650-1000mg every 4-6 hours, for a duration of 3-5 days 1, 2.

Options for Pain Management

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): ibuprofen, 400-800mg every 6-8 hours, or acetaminophen, 650-1000mg every 4-6 hours, for a duration of 3-5 days
  • Oral Opioids: oxycodone, 5-10mg every 4-6 hours, or tramadol, 50-100mg every 4-6 hours, may be prescribed for a limited duration of 3-5 days 3, 4
  • Hormonal Therapies: combined oral contraceptives may be considered for long-term management of ovarian cyst-related pain, with a typical regimen consisting of 20-35mcg of ethinyl estradiol and 0.1-0.3mg of levonorgestrel, taken daily for 21 days, followed by a 7-day hormone-free interval ### Additional Considerations In cases of severe pain, it is essential to consider the use of coanalgesics, such as anticonvulsants (e.g., gabapentin, pregabalin) or antidepressants (e.g., tricyclic antidepressants), to help manage neuropathic pain or reduce systemic opioid requirement 5. Additionally, nonpharmacologic specialty consultations, such as physical therapy or cognitive modalities (e.g., hypnosis, relaxation), may provide beneficial adjuncts to pharmacologic interventions 5. It is crucial to monitor pain ratings and adjust treatment plans accordingly to ensure that the pain remains under good control and goals of treatment are achieved 4, 5.

From the Research

Pain Management Options for Ovarian Cysts

The following options are available for pain management in patients with ovarian cysts:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) available via multiple routes, which can be effective for pain management 6, 7, 8, 9
  • Acetaminophen, which can be used orally or intravenously, and may be associated with a faster onset of action when used intravenously 10
  • Anticonvulsants, which can be especially effective for neuropathic pain associated with trauma or other conditions 10, 8
  • Muscle relaxants and alpha-2 adrenergic agonists, which can be used as adjuvants for pain management 10
  • Ketamine and regional techniques, which can play an important role in multimodal therapy but require medical and nursing support 10
  • Nonpharmacologic treatments, such as cryotherapy, distraction techniques, breathing and relaxation, and acupuncture, which can supplement pharmacologic analgesics and be safe and easy to implement 10, 9
  • Osteopathic manipulative treatment (OMT), which is a conservative, non-pharmacological treatment that can be used to help treat chronic pain associated with various conditions, including osteoarthritis 9
  • Topical NSAIDs, such as diclofenac gel, which can provide an alternative to oral NSAIDs and minimize negative side effects 9

Considerations for Pain Management

When selecting a pain management option, it is essential to consider the individual patient's needs and medical history, as well as the potential risks and benefits of each treatment. For example:

  • NSAIDs can be effective for pain management but may have negative side effects, such as cardiovascular risks, when used chronically 6, 9
  • Opioids can be effective for pain management but may have risks of addiction and other adverse events, and their use should be carefully monitored 10, 7, 8
  • Nonpharmacologic treatments can be safe and effective but may not be suitable for all patients, and their use should be individualized 10, 9

References

Guideline

adult cancer pain.

Journal of the National Comprehensive Cancer Network : JNCCN, 2010

Research

Cardiovascular effects and safety of (non-aspirin) NSAIDs.

Nature reviews. Cardiology, 2020

Research

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective.

Journal of trauma nursing : the official journal of the Society of Trauma Nurses, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.