From the Guidelines
Estriol is not a commonly used medication in the United States, and it is not approved by the FDA for any specific indications. However, it is sometimes used off-label in the form of bioidentical hormone replacement therapy (BHRT) products, such as Estriol tablets or creams, typically in doses ranging from 0.5 to 2 mg per day for menopausal symptom relief, with treatment durations varying depending on individual patient needs 1. Additionally, Estriol is a component of some compounded vaginal creams, often used to treat vaginal atrophy and dryness, typically applied intravaginally in doses of 0.1 to 1 mg per application, 1-3 times a week 1.
Key Points
- Estriol is not FDA-approved for any specific indications in the United States
- It is used off-label in BHRT products for menopausal symptom relief
- Typical doses range from 0.5 to 2 mg per day for menopausal symptoms
- Compounded vaginal creams containing Estriol are used for vaginal atrophy and dryness
- Treatment durations and dosing may vary depending on individual patient needs 1
From the Research
Estriol Use in the United States
- There is no direct evidence in the provided studies that specifically addresses the use of estriol in the United States.
- However, the studies suggest that estriol is used in various countries for the treatment of menopausal symptoms, vaginal dryness, and other conditions 2, 3, 4, 5, 6.
- The studies were conducted in different countries, including Japan and Europe, and the results may not be directly applicable to the United States.
- Nevertheless, the studies provide evidence of the efficacy and safety of estriol for various indications, which may be relevant to its potential use in the United States 2, 3, 4, 5, 6.
Regulatory Status
- The regulatory status of estriol in the United States is not explicitly mentioned in the provided studies.
- However, it is known that estriol is not approved by the US Food and Drug Administration (FDA) for use in the United States, although it is available in some other countries 2.
- The FDA has approved other estrogen products for the treatment of menopausal symptoms and other conditions, but estriol is not among them.
Clinical Use
- The provided studies suggest that estriol may be effective for the treatment of menopausal symptoms, vaginal dryness, and other conditions 2, 3, 4, 5, 6.
- However, the use of estriol in the United States would require FDA approval, which has not been obtained.
- Some studies suggest that estriol may be a safer alternative to other estrogen products, with fewer risks of adverse effects 2, 6.
- Further research is needed to fully understand the potential benefits and risks of estriol and to determine its suitability for use in the United States.