Differential Diagnosis for Plantar Foot Nodule
- Single most likely diagnosis
- Plantar wart: This is the most common cause of a plantar foot nodule, often caused by the human papillomavirus (HPV). The location on the plantar surface and the appearance of the nodule can help differentiate it from other causes.
- Other Likely diagnoses
- Plantar fibroma: A benign growth on the plantar surface of the foot, which can cause discomfort and pain. It is less common than a plantar wart but should be considered in the differential diagnosis.
- Morton's neuroma: Although not typically described as a nodule, it can present as a palpable mass between the toes, causing pain and discomfort.
- Callus or corn: Thickened skin areas due to repeated pressure or friction, which can sometimes be mistaken for a nodule.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Soft tissue sarcoma: Although rare, any unexplained or growing mass should prompt consideration of malignancy, including soft tissue sarcomas like liposarcoma or leiomyosarcoma.
- Infection (e.g., abscess or osteomyelitis): Especially in diabetic or immunocompromised patients, an infectious process can present as a nodule and requires prompt diagnosis and treatment to prevent serious complications.
- Rare diagnoses
- Giant cell tumor of the tendon sheath: A rare, benign tumor that can occur on the foot and may present as a nodule.
- Plantar xanthoma: A rare condition characterized by the accumulation of lipid-laden macrophages in the skin, which can appear as nodules on the plantar surface.
- Foreign body reaction: In cases where a foreign object has penetrated the skin and caused a localized reaction, it could potentially present as a nodule on the plantar surface of the foot.