How to taper someone off Adderall (amphetamine and dextroamphetamine)?

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Last updated: April 22, 2025View editorial policy

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From the Guidelines

Tapering someone off Adderall should always be done under medical supervision, with a gradual dose reduction approach to minimize withdrawal symptoms and psychological distress. Although the provided evidence primarily focuses on opioid tapering, the principles of gradual dose reduction and patient-centered care can be applied to tapering off Adderall as well 1. A typical approach involves gradually reducing the dose by about 25% every 2-4 weeks, adjusting based on withdrawal symptoms. For example, someone taking 20mg twice daily might first decrease to 15mg twice daily for 2-4 weeks, then 10mg twice daily, and so on until completely off the medication.

The tapering schedule should be personalized based on the individual's current dose, duration of use, and response to dose reductions. Key considerations include:

  • The patient's medical history and current health status
  • The presence of any co-occurring mental health conditions
  • The potential for withdrawal symptoms, such as fatigue, depression, increased appetite, or sleep disturbances
  • The need for supportive measures, such as maintaining regular sleep schedules, exercising, and staying hydrated

During tapering, patients may experience withdrawal symptoms because the brain has adapted to Adderall's effects on dopamine and norepinephrine systems and needs time to readjust to functioning without the medication. Supportive measures during tapering include:

  • Maintaining regular sleep schedules
  • Exercising regularly
  • Staying hydrated
  • Possibly using temporary supportive medications for specific symptoms, such as antidepressants or sleep aids

Abrupt discontinuation should be avoided as it can lead to severe withdrawal symptoms and psychological distress. If withdrawal symptoms become severe during tapering, the reduction rate should be slowed down under medical guidance. Clinicians should collaborate with patients and share decision-making about whether and how to taper Adderall, taking into account the patient's perceptions of benefits, risks, and adverse effects of continued therapy 1.

From the FDA Drug Label

DRUG ABUSE AND DEPENDENCE Dextroamphetamine sulfate tablets are a Schedule II controlled substance. Amphetamines have been extensively abused. Tolerance, extreme psychological dependence and severe social disability have occurred. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. The FDA drug label does not answer the question.

From the Research

Tapering Off Adderall

To taper someone off Adderall, it is essential to consider the potential effects of withdrawal and the individual's overall health.

  • The studies provided do not directly address the tapering process for Adderall 2, 3, 4, 5, 6.
  • However, it is known that Adderall is a stimulant medication, and its withdrawal can lead to various symptoms, including fatigue, depression, and insomnia.
  • A gradual tapering schedule, supervised by a healthcare professional, is often recommended to minimize the risk of severe withdrawal symptoms.
  • The healthcare provider will assess the individual's overall health, medical history, and the duration of Adderall use to determine the best tapering strategy.

Considerations for Tapering

When tapering off Adderall, the following considerations are crucial:

  • The dose and frequency of Adderall should be gradually reduced over a period of time, rather than stopping abruptly.
  • The individual's response to the tapering process should be closely monitored, and adjustments made as needed.
  • Supportive care, such as counseling and behavioral therapy, may be necessary to help manage withdrawal symptoms and prevent relapse.

Importance of Medical Supervision

It is essential to emphasize that tapering off Adderall should only be done under the guidance of a qualified healthcare professional.

  • They will be able to assess the individual's specific needs and develop a personalized tapering plan.
  • Medical supervision can help minimize the risks associated with Adderall withdrawal and ensure a safe and successful tapering process 2, 3, 4, 5, 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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