From the Guidelines
Elevated basophils with a normal white blood cell (WBC) count is a condition that warrants medical evaluation to determine the underlying cause, and according to the European LeukemiaNet recommendations, basophils in blood ≥20% can be a criterion for the definition of accelerated phase in chronic myeloid leukemia 1. When considering the management of elevated basophils, it's crucial to rule out underlying conditions such as chronic myeloid leukemia (CML), given that basophilia can be a sign of the accelerated phase of this disease 1. The European LeukemiaNet recommendations provide criteria for defining the accelerated phase, which includes basophils in blood ≥20% 1. Some key points to consider in the evaluation of elevated basophils with normal WBC include:
- Basophilia can be associated with various disorders, including allergic reactions, certain inflammatory conditions, myeloproliferative disorders, hypothyroidism, or recovery from infection.
- A complete blood count with differential, bone marrow examination, or specific allergy testing may be recommended to determine the underlying cause.
- Treatment targets the underlying condition, and no specific medication is universally recommended for basophilia alone.
- Persistent elevation without explanation requires follow-up, as it could indicate a developing condition that needs monitoring or intervention. Given the potential association with serious conditions like CML, it is essential to consult with a healthcare provider for a thorough evaluation and appropriate management of elevated basophils with normal WBC 1.