In a 57‑year‑old woman with a six‑month history of dull nocturnal left shoulder pain radiating to the biceps, limited active and passive internal and external rotation, normal strength, no pain with resisted abduction, external rotation, or forearm supination, and a past history of treated breast cancer and hypothyroidism (levothyroxine), which diagnosis is most consistent: adhesive capsulitis, biceps tendinitis, cervical radiculopathy, or glenohumeral osteoarthritis?

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Adhesive Capsulitis

This patient's presentation is most consistent with adhesive capsulitis (frozen shoulder). The combination of equal restriction in both active and passive internal and external rotation, normal strength on resisted testing, nocturnal pain, and risk factors including breast cancer treatment and hypothyroidism strongly support this diagnosis over the other options 1, 2.

Clinical Reasoning

Key Diagnostic Features Present

  • Equal restriction of active and passive range of motion is the hallmark finding that distinguishes adhesive capsulitis from rotator cuff pathology, where passive motion would be preserved 1, 2

  • External rotation is typically the most severely affected motion in adhesive capsulitis, followed by abduction, then internal rotation—creating the classic "capsular pattern" 1, 2

  • Normal strength with resisted testing excludes rotator cuff tears, which would demonstrate focal weakness during specific resistance maneuvers 1, 2

  • No pain with resisted isometric abduction, external rotation, or forearm supination effectively rules out rotator cuff tendinopathy and biceps tendinitis, as these conditions produce pain with specific resistance testing 2

Risk Factor Profile

  • Breast cancer treatment history is a recognized risk factor for adhesive capsulitis, as cancer-related treatments have been linked to higher incidence of this condition 3, 2

  • Hypothyroidism is a well-established systemic risk factor for developing adhesive capsulitis 2, 4

  • Middle-aged female demographic fits the typical patient profile for primary adhesive capsulitis 5

Why Other Diagnoses Are Excluded

Biceps Tendinitis (Option 2)

  • Would produce pain with resisted supination of the forearm, which this patient does not have 2
  • Typically does not cause global restriction of passive range of motion 2
  • The anterior shoulder tenderness is too vague and medial to the deltoid to localize to the biceps tendon 2

Cervical Radiculopathy (Option 3)

  • Would present with neurologic findings such as dermatomal sensory changes, reflex abnormalities, or weakness in specific nerve root distributions—none of which are present 2
  • Normal strength and sensation in the elbow, wrist, and hand argue strongly against nerve root compression 2
  • Pain pattern does not follow a dermatomal distribution 2

Glenohumeral Osteoarthritis (Option 4)

  • Would typically show crepitus on examination and radiographic changes 6, 7
  • Usually presents with more gradual onset over years rather than six months 7
  • While it can restrict motion, the pattern and severity in a 57-year-old without significant trauma history is less typical 6

Clinical Pitfalls to Avoid

  • Do not confuse adhesive capsulitis with rotator cuff pathology—the key differentiator is that rotator cuff tears show focal weakness with specific resistance testing and preserved passive motion, whereas adhesive capsulitis demonstrates equal restriction in both active and passive motion 1, 2

  • Avoid delaying diagnosis beyond 6-8 weeks, as early intervention with corticosteroid injection and physical therapy may shorten the overall duration of symptoms and prevent permanent functional limitations 2, 8

  • Do not recommend aggressive overhead pulley exercises, as these can worsen shoulder complications, particularly in patients with risk factors like prior cancer treatment 3, 1

Recommended Next Steps

  • Initiate treatment with intra-articular corticosteroid injection targeting the glenohumeral joint (since capsular involvement is predominant) combined with physical therapy emphasizing gentle stretching in external rotation and abduction 1, 8

  • Consider MRI without contrast if the diagnosis remains uncertain or if symptoms do not improve with initial conservative management, as coracohumeral ligament thickening on MRI yields high specificity for adhesive capsulitis 2, 4

  • Prescribe acetaminophen or NSAIDs for routine pain control, provided no contraindications exist 1, 7

  • Refer for physical therapy focusing on gentle range-of-motion exercises, avoiding aggressive passive stretching that could exacerbate symptoms 1, 8

References

Guideline

Frozen Shoulder Clinical Characteristics and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Differentiating Adhesive Capsulitis from Rotator Cuff Syndrome

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Adhesive Capsulitis: Diagnosis and Management.

American family physician, 2019

Research

[Adhesive capsulitis].

Radiologie (Heidelberg, Germany), 2024

Guideline

Adhesive Capsulitis in Post-Stroke Patients

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Adhesive capsulitis: a review.

American family physician, 2011

Research

Treatment of Adhesive Capsulitis of the Shoulder.

The Journal of the American Academy of Orthopaedic Surgeons, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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