How should I modify my insulin regimen for type 2 diabetes mellitus (treated with sitagliptin (Jordiance) 25 mg daily, insulin glargine (Lantus) 18 U in the morning, and insulin lispro (Humalog) 4–6 U with meals) given an average fasting glucose of 106 mg/dL with symptomatic hypoglycemia when <100 mg/dL and a 9 pm glucose of 300 mg/dL despite unchanged diet?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board

Educational purpose only • Exercise caution as content is pending human review

Article Review Status

Submitted

Under Review

Approved

Last updated: February 14, 2026 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What are the management considerations for an adult patient with type 2 diabetes mellitus prescribed Sitagliptin 50 mg twice daily?

For an adult with type 2 diabetes currently taking sitagliptin 50 mg twice daily, what is the appropriate dosing regimen for Invokana (canagliflozin)?

What are the contraindications for starting vidagliptin (sitagliptin) in a patient with type 2 diabetes and impaired renal (kidney) function or hepatic (liver) impairment?

Can sitagliptin (Januvia) be used in conjunction with Ozempic (semaglutide) in patients with type 2 diabetes?

Can a patient with type 2 diabetes mellitus (T2DM) and stable renal function take sitagliptin (DPP-4 inhibitor) and empagliflozin (SGLT2 inhibitor) at the same time?

What is the recommended oral baclofen dosing and titration schedule for an adult with post‑stroke spasticity?

How should a solitary left ureteric stone measuring about 4.5 mm × 3.8 mm with grade 1 hydroureteronephrosis be managed?

What changes have occurred in the risk profile for coronary heart disease over the past decade, including shifts in modifiable risk factors such as smoking, obesity, diabetes, sedentary behavior, and differences by age and sex?

What are the indications, dosing schedule, contraindications, and common adverse effects of Pulmoclear (acebrophylline 100 mg/N‑acetylcysteine 600 mg) tablets?

What is the most likely diagnosis for a 35‑year‑old aerobic dance instructor who has anterior thigh pain, painful limitation of hip internal rotation, weight‑bearing pain, limp, and pain when hopping, without tenderness or muscle weakness?

What is the appropriate citalopram dose when converting a patient from escitalopram 5 mg?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.