From the Research
Hyperparathyroidism does not typically cause testicular pain. The primary symptoms of hyperparathyroidism include bone pain, kidney stones, abdominal pain, fatigue, depression, and cognitive issues, as noted in a study published in the Journal of Clinical Medicine in 2021 1. Testicular pain is not a recognized manifestation of hyperparathyroidism, and its pathophysiology involves disruption of calcium homeostasis affecting primarily the skeletal system, kidneys, and gastrointestinal tract, but not typically the male reproductive organs. If a patient is experiencing testicular pain, other causes should be investigated, such as:
- Epididymitis
- Orchitis
- Testicular torsion
- Inguinal hernia
- Kidney stones that may refer pain to the testicles
- Trauma A study published in Best Practice & Research Clinical Rheumatology in 2020 2 also supports the fact that primary hyperparathyroidism manifestations have changed over time, but testicular pain is not mentioned as a symptom. Therefore, if a patient with hyperparathyroidism reports testicular pain, the two conditions are likely unrelated, and separate evaluation of the testicular pain is warranted.